| 摘要 |
Objective: The mortality rate of patients with cutaneous combined burns with
smoke inhalation injury is reported to be much higher than that of patients with
either injury alone. Patients with such combined injury need a more intensive and
aggressive nutrition supply to help them survive. The present study was designed to
test amino acid flux in cases of combined injury (smoke inhalation injury and cutaneous
burns). The purpose was to understand the amino acids flux after such combined
injury.
Methods: Adult male rats were divided 3 groups, non-injury control, smoke
inhalation injury and smoke inhalation injury plus cutaneous burns groups. Rats
received smoke inhlalation injury with/without major cutaneous thermal injury
(40%BSA). Blood was taken from the tail and storaged along with plasma daily for 5
days. Four different amino acids, glutamate, glutamine, arginine and methionine
were tested by HPLC and statistically analyzed.
Results: Our preliminary results showed that smoke inhalation injury alone did not
cause a significant change in amino acids flux during the first 5 days after injury, and
the only increase in arginine was observed on the 3rd day after injury (↑ 27~30%,
p>0.05, non-significant). In the cutaneous burn plus smoke inhalation injury group,
all four amino acids decreased immediately and significantly.
Conclusions: These results suggest that the four non-essential amino acids (glutamine,
glutamate, methionine and arginine) are all conditionally essential amino acids
in this combined injury (cutaneous burn plus inhalation injuries). However, in the
simple smoke inhalation injury group, the amino acids supply was not as important,
at least, in the first 5 days after injury. |
