| 摘要 |
Late sequelae of breast/chest wall and axilla radiotherapy, such as painful edema, lymphoedema of arm, limitation of movement, nonhealing ulcers, and radionecrosis of deep tissues, usually respond poorly to ordinary treatments. Six women, at least three years after breast cancer treatment, were treated with hyperbaric oxygen for their radiation sequelae. Clinical manifestations and local tissue oxygenation were recorded. Under a protocol of 100% oxygen at 2.5 absolute atmosphere, 100 minutes per day, for six days per week, most symptoms relieved and local tissue oxygenation compatibly increased by an average of 250%. A case with extenxive bone destruction subsequently underwent a successfully reconstructive surgery. This limited case report supports the use of adjunctive hyperbaric oxygen therapy in treating post-radiation breast/chest wall/axilla sequelae. Surgical intervention is always needed for radio-necrotic tissues, especially for cases with entensive chest wall and bony necrosis. Transcutaneous tissue oxygen measurement may be a simple noninvasive test to predict the efficiency of hyperbaric oxygen therapy in these cases. |
