台灣外科醫學會雜誌

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篇名	The capabilities of benzoporphrin: In vivo study of canine malignant melanomas with photodynamis tgerapy
作者	Cheng-Jen Chang, Chen-Nun Chang, Tsann-Lang Hwang
卷期/出版年月	35卷4期 (2002/8)
頁次	166-172
摘要	Human malignant melanomas are a kind of commenly occurring neoplasm with a clinical of recurrence after surgical removal. This preliminary animal study seeks to evalute the effect of benzoporphyrin derivative (BPD) in photodynamic therapy (PDT) for spontaneously arising melanoma in canines. The dogs with spontaneously occurring melanomas were treated with PDT using BPD as the photosensitizer. BPD was injected intravenously at a dose of 1 mg/kg. Six hours later the treatment of PDT with 690 nm light was taken. Some larger tumors (>1.5 cm deep) were surgically debulked prior to PDT. No sighificant systemic toxicity or skin photosensitization was observed. PDT with BPD led to a complete reponse in 70% (7 of 10) of these cases. 20% (2 of 10) had a partial response, and 10% (2 of 10) no response (<50% reduction of tumor size). BPD-PDT appears to have advantages in the treatment of canine melanomas, and systemic toxicity is almost nonexistent. Further studies of the long results are necessary before BPD-PDT canbe used in humans.
關鍵詞	Melanoma, photosensitizer, photodynamic therapy
分類	Original Article