| 篇名 |
The analgesic effect of nalbuphine and its long-acting prodrug, nalbuphine arachidicate, in rats |
| 作者 |
Huo-Feng Huang, Yoa-Pu Hu, Shung-Tai Ho, Yi-Ling Chen, Jhi-Joung Wang |
| 卷期/出版年月 |
35卷6期 (2002/12) |
| 頁次 |
283-289 |
| 摘要 |
Nalbuphine is anopioid-analgesic with agonist-antagonist properties. Recently, we synthesized a nalbuphine prodrug, nalbuphine arachidicate. The aim of the present study was to evaluate the analgesic effect and the analgesic duration of this prodrug. Male Sprague-Dawley rats (n=10 in each group) were used. Nalbuphine arachidicate was prepared in an oily solution dosage form and injected intramuscularly at a dosage of 25 umol/kg. A nalbuphine HCI solution was injected intramuscularly at a dosage of 25 umol/kg in the control group. The analgesic effect of nalbuphine arachidicate was assessed using the cold-ethanol tail-flick test (-20℃) and compared with that of nalbuphine HCI. The results show that both nalbuphine arachidicate and nalbuphine HCI demonstrate significant analgesic effects. The analgesic duration of nalbuphine arachidicate (78 h) was much longer than that of nalbuphine HCI (2h). This fascinating finding is worthy of further evaluation. |
| 關鍵詞 |
Analgesia, nalbuphine, nalbuphine arachidicate, long-acting, prodrug |
| 分類 |
Original Article |
