| 摘要 |
Objective: Breast cancer is a rare disease in men, and knowledge relevant to male breast cancer is still limited. This reports our experience with this disease during a 13-year period at Mackay Memorial Hospital.
Patients and Methods: From 1987 to 2000, 13 men with primary breas carcinoma were treated at the Department of General Surgery. We retrospectively reviewed their clinical and pathological data, as extracted from hospital admission and discharge summaries, progress notes, operative notes, laboratory reports, and pathology reports. Both demographic characteristics and tumor-associated factors were notes. Staging was carried out according to the guidelines of the American Joint Committee on Cancer (AJCC,1992), as used in women with breast cancer.
Results: Six of the 13 patients are currently alive without evidence of disease, while 4 of 13 died with a median survival of 44 months. Exclusively, death was due to other medical conditions (2 upper gastrointestinal bleeding and 1 acute myocardial infarction).In our series, the 5-year disease free survival is zero for stage III & IV, 33% for stage II, 100% for stage I & 0.
Conclusions: As in women, advanced TNM stage was associated with diminished survival. However, male breast cancer differs biologically from female breast cancer, with a higher incidence of estrogen and progeaterone receptor positivity. Sixty nine percent of our patients had a positive expression. Adjuvant hormonal or chemotherapy, or both, is based largely on the benefits observed in clinical trials in women with breast cancer, but optimal treatment protocols in males are unknown. Further research is needed in male breast cancer to develop optimal treatment strategies. |
