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篇名 Head‑and‑neck paragangliomas
作者 Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
卷期/出版年月 53卷3期 (2020/6)
頁次 121-122
摘要 Dear Editor, We read the article entitled, “Multiple paragangliomas involving the carotid body and vagal region” on the esteemed “Formosan Journal of Surgery” with great interest. Bakshi et al. reported a case of an adult male with a swelling in the left upper part of the neck. Their report is the second case of multiple paragangliomas affecting the carotid body and vagal region.[1] A systematic review of the genetic analysis of paragangliomas from head and neck showed that 10 out of 15 genes only when mutated can turn the individual susceptible to the development of these tumors. In this way, they discussed the influence of the main genetic drivers on the somatic molecular phenotype showed by DNA methylation and microRNA profiling. They stated that assuming a case of sporadic without doing a careful clinical observation could lead to a high number of misdiagnosis. Some of the genetic mutations associated with paragangliomas can skip generations or have variable penetrance, so in every case where these tumors are encountered a pedigree description should be done.[2] An interesting fact is about how much a metastasis in the regional lymph nodes can affect the survival rate. Javidiparsijani et al. in their retrospectively study on 65 patient charts found that about 50% of the patients had regional lymph node biopsy positive. After they evaluate the follow‑up of these individuals, no evidence of local recurrence or distant metastasis in the patients with positive lymph nodes was found within 6–11 years of follow‑up. Therefore, in most cases where there is metastasis to local lymph nodes, an indolent course is observed however, if a positive lymph node is noted in the sclerosing variant, the prognosis is worst.[3] Another recent study by Singh et al. has evaluated the epidemiological profile, clinicopathological correlation, and management of head‑and‑neck paragangliomas in 54 Indian individuals. Their study revealed that the site with the largest and most common paragangliomas is the carotid body in the head‑and‑neck region.[4] We would like to provide the mnemonic “CAROT ↑ DS” to help remember the main facts about the head‑and‑neck paragangliomas: Carotid body tumors are the largest and most common paragangliomas of the head and neck. Autonomic neoplasm origin can be classified based on the lesion site. RET, SDHB, SDHD, and VHL germline mutations are associated with familial cases. Occurrence in the head and neck is about 3% of all paragangliomas. Tumor resection is one of the management options but does not improve life expectancy. ↑: More upper (↑) in the body is more probable the P(↑) arasympathetic origin. Death and morbidity are more common with glomus jugulotympanicum tumors. Sclerosing variant of paraganglioma has a more aggressive histological behavior, especially when lymph nodes are positive.[1‑5]
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分類 Letter to the Editor

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