|
|
第57卷 第2期 2024-3
Necrotizing fasciitis resulted from foreign body ingestion and intestinal perforation in an incisional hernia: Report of a case |
| ......................... |
|
第57卷 第2期 2024-3
Application of artificial intelligence in endodontic microsurgery |
| ......................... |
|
第57卷 第2期 2024-3
A rare case of cerebral metastasis of malignant peripheral nerve sheath tumor in a patient with neurofibromatosis type 1 |
| ......................... |
|
第57卷 第2期 2024-3
Ethic in commenting and clinical surgery journal publication: Emerging issue in the era of social media—A story from “Beall” to “Jaime” and independent researcher |
| ......................... |
|
第57卷 第2期 2024-3
Ophidascaris robertsi, the new emerging human parasite and neurosurgery |
| ......................... |
|
第57卷 第2期 2024-3
Tetanus toxoid IgG, usefulness in clinical surgery, and diagnostic property limitation |
| ......................... |
|
第57卷 第2期 2024-3
Deaths among surgeons while on duty: An important issue in surgery and occupational medicine that should not be disregarded |
| ......................... |
|
第57卷 第2期 2024-3
ChatGPT and its use in clinical surgery: A comment on its pro and con |
| ......................... |
|
第57卷 第2期 2024-3
Isolated spinal neurocysticercosis and pseudotumor cerebri: Tropical problem to be noted |
| ......................... |
|
第57卷 第2期 2024-3
Management of massive hemothorax resulting from traumatic diaphragm rupture with kidney avulsion injury by combined anterior thoracoabdominal approaches |
| ......................... |
|
第57卷 第2期 2024-3
Laparoscopic partial splenectomy for sclerosing angiomatoid nodular transformation: A case report and literature review |
| ......................... |
|
第57卷 第2期 2024-3
Using three-dimensional versus two-dimensional laparoscopy in sleeve gastrectomy: A case matched comparison |
| ......................... |
|
第57卷 第2期 2024-3
Effectiveness of placing prophylactic mesh with the Sugarbaker technique via laparoscopic abdominoperineal resection for rectal cancer: 1-year results |
| ......................... |
|
第57卷 第2期 2024-3
Nylon cable ties–assisted delay primary closure of fasciotomy wound in patients of forearm compartment syndrome |
| ......................... |
|
第57卷 第2期 2024-3
Prefabricated venous fl ap, an advanced free venous fl ap for distant transfer: An experimental rat study |
| ......................... |
|
第57卷 第1期 2024-1
Isolated lower leg monoplegia due to traumatic intraparenchymal hemorrhage |
| ......................... |
|
第57卷 第1期 2024-1
Reflections on the association between cholecystectomy, cholelithiasis, and colorectal cancer |
| ......................... |
|
第57卷 第1期 2024-1
Molluscum contagiosum, false positive, and incidence: Concern in surgery |
| ......................... |
|
第57卷 第1期 2024-1
New form of COVID-19 vaccine: A new advanced technology for fighting the remained problem |
| ......................... |
|
第57卷 第1期 2024-1
COVID-19 vaccination, acute appendicitis, interrelationship, and jointed probability: A concern |
| ......................... |
|
 |
| 篇名 |
Convection-Enhanced Delivery: an Emerging Technique for Outwitting the Blood-Brain Barrier |
| 作者 |
John-S Kuo, Chi-Cheng Tu |
| 卷期/出版年月 |
39卷4期 (2006/8) |
| 頁次 |
216-221 |
| 摘要 |
The blood-brain barrier (BBB) is a formidable obstacle preventing efficient delivery
of therapeutic agents to the central nervous system (CNS). High peripheral dosing of
CNS drugs often leads to unwanted systemic side effects. Direct introduction of
therapeutic molecules into the CNS can bypass the BBB, but limited diffusion,
metabolism, and capillary clearance confine their effective range. An emerging
technology, convection-enhanced delivery (CED), successfully overcomes these
barriers to disseminate CNS therapies. CED utilizes the principle of continuous
interstitial macromolecular infusion with a positive pressure gradient through
surgically-implanted microcatheters to safely target CNS lesions. The following CEDbased
anti-tumor therapies are being investigated in clinical trials: 1) recombinant
immunotoxins or bacterial toxins specifically targeted to tumor cell surface molecules
(interleukin-immunotoxin, transferrin-diphtheria toxin), 2) viral thymidine kinase
gene that cooperatively act with the chemotherapy agent, gancyclovir. CED can also
introduce anti-infection drugs, metabolic agents to stimulate or ablate functional
brain domains, and has the potential to be an effective and versatile technology for
delivering future therapies in treating neurodegenerative diseases via stem cell or
other novel strategies. |
| 關鍵詞 |
blood-brain barrier, central nervous system, convection-enhanced delivery, immunotoxins, surgical technique |
| 分類 |
Advance in Brief |
|
