中文 | ENG

第57卷 第1期 2024-1
Isolated lower leg monoplegia due to traumatic intraparenchymal hemorrhage

.........................

第57卷 第1期 2024-1
Reflections on the association between cholecystectomy, cholelithiasis, and colorectal cancer

.........................

第57卷 第1期 2024-1
Molluscum contagiosum, false positive, and incidence: Concern in surgery

.........................

第57卷 第1期 2024-1
New form of COVID-19 vaccine: A new advanced technology for fighting the remained problem

.........................

第57卷 第1期 2024-1
COVID-19 vaccination, acute appendicitis, interrelationship, and jointed probability: A concern

.........................

第57卷 第1期 2024-1
Role of clinical surgery in management of adverse effect of COVID-19 vaccine

.........................

第57卷 第1期 2024-1
Trends in global research for treating COVID-19 vaccine–related acute appendicitis: A bibliographic analysis

.........................

第57卷 第1期 2024-1
Heterologous vaccination, from rabies vaccine to COVID-19 vaccine: View in clinical surgery

.........................

第57卷 第1期 2024-1
A huge gastric trichobezoar presenting with Rapunzel syndrome: A case report

.........................

第57卷 第1期 2024-1
Multidisciplinary team approach for treating recurrent gastrointestinal bleeding caused by a Dieulafoy lesion

.........................

第57卷 第1期 2024-1
Early decompressive surgery within 72 hours of admission maintains financial advantages for patients with spinal epidural abscess, as evidenced by a retrospective study involving 130 cases

.........................

第57卷 第1期 2024-1
Laparoscopic versus open liver resection for treatment of liver tumors: Early experience outcomes

.........................

第57卷 第1期 2024-1
Hepatobiliary surgery in Taiwan: The past, present, and future. Part I; biliary surgery

.........................

第56卷 第6期 2023-11
New generation of COVID-19 vaccine, new form and new material: What to know in clinical surgery

.........................

第56卷 第6期 2023-11
Jejunojujunal intussusception as a rare complication of feeding jejunostomy

.........................

第56卷 第6期 2023-11
Aortic valve myxoma presenting with sudden visual loss

.........................

第56卷 第6期 2023-11
Candida auris and new concern in clinical surgery

.........................

第56卷 第6期 2023-11
Intra-abdominal paragonimiasis abscess: A note on rare recurrent acute abdomen disease

.........................

第56卷 第6期 2023-11
Death due to rabies after animal bite injury: Incidence pre– and post–COVID-19

.........................

第56卷 第6期 2023-11
Mortality rate due to traffic accident: What is it about its pattern with specific focus on relationship to COVID-19 outbreak?

.........................
登入帳號才能閱讀全文
 
篇名 Differential impacts of clinical variables and 5‑fluorouracil‑based adjuvant chemotherapy on 5‑year disease‑free survival of patients with stage IIa and IIb colon cancer
作者 Yi‑Hung Kuo, Cheng‑Yi Huang, Chih‑Chien Chin, Chih‑Jung Chen, Wen‑Shih Huang, Jeng‑Fu You, Yun‑Ching Huang
卷期/出版年月 51卷2期 (2018/4)
頁次 41-49
摘要 Background: The aim of this study was to evaluate practicable predictors of 5‑year disease‑free survival (DFS) and impact of 5‑fluorouracil (5‑FU)‑based adjuvant chemotherapy in stage IIa and IIb colon cancer. Materials and Methods: A total of 1474 patients with stage II colon cancer were enrolled in study. The independent predictors of 5‑year DFS and the benefits of adjuvant chemotherapy were analyzed for patients with stage IIa (n = 771) and IIb (n = 703). Results: The incidences of pretreatment anemia, hypoalbuminemia, emergent surgery, and lymphovascular invasion (LVI) corresponded significantly to an advanced T‑stage in patients with stage II colon cancer. Although the incidence of surgical morbidity was not different between stage IIa and IIb, stage II patients with hypoalbuminemia had a higher incidence of surgical morbidity than did those with normal serum albumin (17.2% vs. 9.6%, P < 0.001). The co‑independent survival predictors in patients with stage IIa and IIb colon cancer were carcinoembryonic antigen (CEA < 5 ng/mL, P = 0.007 and 0.043), serum albumin (≥3.5 g/dL, P < 0.001 and P = 0.025), and nonsurgical morbidity (P < 0.001, both). Suboptimal lymph node harvest (<12 examined nodes, P < 0.001) and no adjuvant chemotherapy (P = 0.008) were poor prognostic factors only in stage IIb colon cancer. LVI showed a trend to worse DFS (P = 0.059). A survival benefit from adjuvant chemotherapy analyzed in four subgroups stratified by stage IIa and IIb, with or without the present prognostic factors, was only observed in patients with stage IIb colon cancer with hypoalbuminemia, abnormal CEA, suboptimal lymph node harvest, and postoperative morbidity. Conclusion: Different predictors of DFS were observed in stage IIa and IIb colon cancer; adjuvant chemotherapy could provide a survival benefit for patients with stage IIb colon cancer who have one of the four factors that were studied in our hospital‑based analysis.
關鍵詞 Adjuvant chemotherapy, carcinoembryonic antigen, hypoalbuminemia, morbidity, survival of stage II colon cancer
分類 Original Article

台灣外科醫學會雜誌 © 2006 Taiwan Surgical Association All Rights Reserved
會 址:台北市南京東路五段 31 號 3 樓
電 話:(02) 2769-7845 傳 真:(02) 2746-7149 Email: journal@24drs.com