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| 篇名 |
Hyperbaric oxygen therapy for hemorrhagic radiation cystitis |
| 作者 |
Kung-Hung Lin, Hui-Chieh Lee, Wen-Shyan Huang, Po-Wei Huang, Seng-Chung Ke, Man-Gang Le |
| 卷期/出版年月 |
50卷2期 (2017/4) |
| 頁次 |
52-56 |
| 摘要 |
Background: Radiation cystitis with macroscopic hematuria is a frustrating clinical problem for urologists. Since 1985, hyperbaric oxygen therapy (HBOT) has been applied as a treatment for radiation cystitis with macroscopic hematuria; numerous studies have shown that this treatment has favorable results.
Purpose: The purpose of this study was to elucidate the HBOT affected the clinical outcomes and treatment of hemorrhagic radiation cystitis (HRC).
Methods: Between November 1989 and June 2014, 42 patients (39 women and three men) with HRC were treated with hyperbaric oxygen at a pressure of 2.5 atmospheres absolute, breathing 100% O2 for 120 min in a multiplace hyperbaric chamber.
Results: After an average of 38 hyperbaric oxygen sessions, macroscopic hematuria was completely halted in 35 patients (83.3%) and markedly decreased in three patients (7.1%). A comparison of cystoscopic findings before and after HBOT showed significant decreases in both hemorrhagic sites and telangiectasis of the bladder mucosa. The mean follow-up was 20.7 months (range: 3–49 months). No cases exhibited evidence of barotrauma or oxygen toxicity. One patient underwent a urodynamic study both before and after HBOT, with several changes in bladder function observed after HBOT: urine peak flow increased from 12.8 mL/s before HBOT to 15.0 mL/s after HBOT and urine mean flow increased from 6.5 mL/s to 8.9 mL/s. Urine voiding time decreased from 40.0 s to 28.0 s, urine flow time from 39.0 s to 28.0 s, time
to peak flow from 15.0 s to 8.0 s, and voided volume from 251 mL to 248 mL.
Conclusion: The results of this study suggest that early application of HBOT is a safe and effective treatment method for HRC. Whether HBOT is beneficial to urinary bladder function requires further study with a larger patient cohort enrolled. |
| 關鍵詞 |
Hemorrhagic radiation cystitis, hyperbaric oxygen therapy, urodynamic |
| 分類 |
Original Article |
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