| 篇名 |
Prognostic effects of O6-Methylguanine DNA methyltransferase promoter hypermethylation in high-grade glioma patients with carmustine wafer implants |
| 作者 |
Mao-Yu Chen, Ping-Ching Pai, Shih Ming Jung, Chi-Cheng Chuang, Chen-Nen Chang, Kuo-Chen Wei |
| 卷期/出版年月 |
50卷2期 (2017/4) |
| 頁次 |
45-51 |
| 摘要 |
Background: Local chemotherapy with carmustine (BCNU) wafer implantation has survival benefits for malignant glioma patients. However, available data regarding its association with O6-methylguanine-DNA-methyltransferase (MGMT) are scant.
Purpose: To evaluate whether MGMT hypermethylation has prognostic effects in malignant glioma patients with interstitial BCNU wafer implants.
Methods: From September 2004 to August 2007, 32 patients with malignant gliomas underwent surgical resection plus interstitial BCNU wafer implantation at our hospital.
Results and Conclusion: BCNU wafer implantation was performed in 18 patients with newly diagnosed gliomas All patients had a karnofsky performance status of ≧70. The median age was 51 years. At a median follow-up of 31 months, the 1- and 2-year overall survival (OS) rate was 43% and 22%, respectively. OS rates did not significantly differ between the newly diagnosed and recurrent patients. Gross total tumor resection was achieved in 19 (59%) patients, and MGMT hypermethylation was noted in 13 (41%) tumor specimens. Multivariate analysis demonstrated that patients with MGMT hypermethylation in their tumors and gross total tumor removal have more favorable survival rates (P = 0.03). |
| 關鍵詞 |
Carmustine wafer, glioblastoma multiforme, gross total resection, high-grade gliomas, O6-methylguanine-DNA-methyltransferase |
| 分類 |
Original Article |
