| 摘要 |
Background/Introduction: Ischemic preconditioning is a method in which brief periods of ischemia render tissues resistant to injury resulting from prolonged ischemia and reperfusion, so-called ischemiaereperfusion injury.
Purpose: To elucidate the possible protective role of ischemic preconditioning in rat livers with ischemiaereperfusion injury.
Methods: Rats were first allocated to either a shamcontrol or an ischemic preconditioning group. On the following day, the rats fromeach group were administered either 30minutes or 45 minutes hepatic ischemia. Next, rat livers were harvested formeasuring proliferating cell nuclear antigen, heme oxygenase-1, inducible nitric oxide synthase, and heat shock protein 70 mRNA levels.
Results: Both proliferating cell nuclear antigen andhemeoxygenase-1 expression increased significantly after 45 minutes hepatic ischemia comparedwith those after 30 minutes hepatic ischemia, but they decreased significantly with ischemic preconditioning. However, ischemic preconditioning did not affect inducible nitric oxide synthase or heat shock protein 70 expression.
Conclusion: From the preliminary findings, further elucidation is warranted. |
