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| 篇名 |
Effects of tamoxifen on traumatic brain injury-induced depression in male rats |
| 作者 |
Che-Chuan Wang, Hsiao-Yue Wee, Chung-Ching Chio, Chiao-Ya Hu, Jinn-Rung Kuo |
| 卷期/出版年月 |
49卷3期 (2016/6) |
| 頁次 |
101-109 |
| 摘要 |
Background/Introduction: Previous studies have investigated the neuroprotective
effects of tamoxifen (TMX), but its antidepressant-like effects in traumatic brain injury (TBI) remain unclear.
Purposes/Aims: The present study was conducted to determine whether TMX can attenuate TBI-induced depression-like behavior and whether this effect involves the activation of extracellular signal-regulated kinase 1/2 (ERK1/2).
Methods: Anesthetized male SpragueeDawley rats were divided into four groups: shamoperated controls, TBI controls, TBI + TMX treatment (1 mg/kg), and TMX (1 mg/kg) + ERK1/2 antagonist, SL327 (30 mg/kg). Depression-like behaviors were evaluated through forced swim tests on Day 4, Day 8, and Day 15. On Day 15 after TBI, phosphorylated ERK1/2 (p-ERK1/2) expression was investigated by Western blotting; neuronal apoptosis, p-ERK1/2, B-cell chronic lymphocytic leukemia/lymphoma 2 (BCL2), and brain-derived neurotrophic factor(BDNF ) expression in neuronal cells were evaluated using double immunofluorescence.
Results: On Day 15 after TBI, TMX significantly reduced the duration of TBI-induced immobility compared with the TBI controls. The frequency of neuronal apoptosis and numbers of BCL2-positive, BDNF-positive, and p-ERK1/2-positive neuronal cells in hippocampal CA3 were significantly improved by TMX. However, these TMX effects were significantly blocked by SL327 administration.
Conclusion: Our results suggest that intraperitoneal injection of TMX may ameliorate TBIinduced depression-like behavior in rats by increasing neuronal p-ERK1/2 expression, which may be associated with neuronal Bcl2 and BDNF expression and decreased neuronal apoptosis.This effect might represent a mechanism underlying the recovery from depression-like behavior. |
| 關鍵詞 |
depression-like behavior;extracellular signalregulated kinases;forced swim test;selective estrogen receptor modulator;tamoxifen |
| 分類 |
Original Article |
|
