中文 | ENG

第58卷 第1期 2025-1
Ensuring authorship qualification in clinical research articles: A focus on surgical therapy studies

.........................

第58卷 第1期 2025-1
Estimated risk for transfusion of monkeypox contaminated perioperative blood transfusion: A call to action for stronger regulations and testing protocols

.........................

第58卷 第1期 2025-1
Insights into traumatic and crisis surgery: Implications of data analysis in conflict zones

.........................

第58卷 第1期 2025-1
Tongue peeling as an adverse reaction with use of micronized purified flavonoid: A case report

.........................

第58卷 第1期 2025-1
Pilonidal sinus of scrotum: A rare clinical entity

.........................

第58卷 第1期 2025-1
Incidental autopsy finding of retiform hemangioendothelioma of the spleen

.........................

第58卷 第1期 2025-1
Retroperitoneal laparoscopy for hydronephrosis due to multiple fibroepithelial polyps: A case series

.........................

第58卷 第1期 2025-1
Case reports of type 1 cystic biliary atresia—A rare variant of biliary atresia alongwith reviewof literature

.........................

第58卷 第1期 2025-1
The predictors of intraoperative surgical expenses in liver resection for hepatocellular carcinoma

.........................

第58卷 第1期 2025-1
Intracorporeal anastomosis versus extracorporeal anastomosis following laparoscopic right hemicolectomy: Surgical outcomes of a single-center observational study

.........................

第58卷 第1期 2025-1
Quality of life and spiritual health in motorcycle accident survivors: An analysis using the SF-36 Questionnaire and Spiritual Scale

.........................

第58卷 第1期 2025-1
Plastin 3 expression in circulating tumor cells as a predictor of cancer status in patients with prostate cancer

.........................

第57卷 第6期 2024-11
Emerging robot-guided techniques in endodontic microsurgery

.........................

第57卷 第6期 2024-11
Management of subcapsular hematoma after living donor liver transplant

.........................

第57卷 第6期 2024-11
Urethral pseudodiverticulum with left-sided nonfunctioning kidney: Case report

.........................

第57卷 第6期 2024-11
Strategy to minimize surgical defect of dermatofi brosarcoma protuberans

.........................

第57卷 第6期 2024-11
Rapunzel syndrome—An uncommon disease with varied common presentations

.........................

第57卷 第6期 2024-11
Minimally invasive approaches to management of acute necrotizing pancreatitis

.........................

第57卷 第6期 2024-11
Innovative surgical technique: Addressing ethical concerns

.........................

第57卷 第6期 2024-11
Emergency surgery and HIV screening, clinical or universal scenarios?

.........................
登入帳號才能閱讀全文
 
篇名 Effects of tamoxifen on traumatic brain injury-induced depression in male rats
作者 Che-Chuan Wang, Hsiao-Yue Wee, Chung-Ching Chio, Chiao-Ya Hu, Jinn-Rung Kuo
卷期/出版年月 49卷3期 (2016/6)
頁次 101-109
摘要 Background/Introduction: Previous studies have investigated the neuroprotective effects of tamoxifen (TMX), but its antidepressant-like effects in traumatic brain injury (TBI) remain unclear. Purposes/Aims: The present study was conducted to determine whether TMX can attenuate TBI-induced depression-like behavior and whether this effect involves the activation of extracellular signal-regulated kinase 1/2 (ERK1/2). Methods: Anesthetized male SpragueeDawley rats were divided into four groups: shamoperated controls, TBI controls, TBI + TMX treatment (1 mg/kg), and TMX (1 mg/kg) + ERK1/2 antagonist, SL327 (30 mg/kg). Depression-like behaviors were evaluated through forced swim tests on Day 4, Day 8, and Day 15. On Day 15 after TBI, phosphorylated ERK1/2 (p-ERK1/2) expression was investigated by Western blotting; neuronal apoptosis, p-ERK1/2, B-cell chronic lymphocytic leukemia/lymphoma 2 (BCL2), and brain-derived neurotrophic factor(BDNF ) expression in neuronal cells were evaluated using double immunofluorescence. Results: On Day 15 after TBI, TMX significantly reduced the duration of TBI-induced immobility compared with the TBI controls. The frequency of neuronal apoptosis and numbers of BCL2-positive, BDNF-positive, and p-ERK1/2-positive neuronal cells in hippocampal CA3 were significantly improved by TMX. However, these TMX effects were significantly blocked by SL327 administration. Conclusion: Our results suggest that intraperitoneal injection of TMX may ameliorate TBIinduced depression-like behavior in rats by increasing neuronal p-ERK1/2 expression, which may be associated with neuronal Bcl2 and BDNF expression and decreased neuronal apoptosis.This effect might represent a mechanism underlying the recovery from depression-like behavior.
關鍵詞 depression-like behavior;extracellular signalregulated kinases;forced swim test;selective estrogen receptor modulator;tamoxifen
分類 Original Article

台灣外科醫學會雜誌 © 2006 Taiwan Surgical Association All Rights Reserved
會 址:台北市南京東路五段 31 號 3 樓
電 話:(02) 2769-7845 傳 真:(02) 2746-7149 Email: journal@surgery.org.tw