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篇名 Challenge of safety margin in laparoscopic liver resection for hepatocellular carcinoma
作者 Chen-Guo Ker, Hong-Yaw Chen, Hsi-Jung Chen, I-Hao Tseng, Yu-Jou Tsai, Hoi-Wan Lo, Chung-Chou Juan
卷期/出版年月 47卷5期 (2014/10)
頁次 183-188
摘要 Background: Advances in minimally invasive surgical techniques and instrumentation have facilitated their application in the management of hepatic tumors. However, determination of the optimal safety margin can be challenging for liver surgeons. The present study used a case-matched analysis to evaluate the surgical margins and survival rates in patients with liver cancer treated using either laparoscopic or traditional liver resection. Methods: All of the enrolled patients were diagnosed with hepatocellular carcinoma (HCC) after surgical resection, which was performed according to clinical practice guidelines. The indications for laparoscopy included the detection of a tumor at the anterior peripheral region of Segments III, IV, V, and VI, with a diameter of < 5 cm. Of all the enrolled patients, 86 (63 men and 23 women) underwent laparoscopic liver resection (Group I), whereas the remaining 91 (67 men and 24 women) underwent traditional open resection (Group II) based on case-matched study. Results: The resection margins were  10 mm, 5e9 mm, and  4 mm in 1 patient, 70 patients, and 15 patients in Group I and 3 patients, 41 patients, and 47 patients in Group II, respectively. The safety margin was ≧ 10 mm in 15 Group I patients (17.4%) and 47 Group II patients (51.6%), respectively, (p = 0.001). The feasibility of wide resection was probably limited by the location of the tumor based adjacent to the main vessels. Overall, in Group I, the 1-, 3-, and 5-year survival rates were 84.2%, 67.3%, and 57.7% for a 5-9-mm safety margin and 93.3%, 86.7%, and 78.0% for a ≧ 10-mm safety margin, respectively; however, these differences were not statistically significant (p = 0.139). Similarly, in Group II, no significant differences were observed regarding the survival rates for varying safety margins (5-9 mm and 10 mm; p = 0.57). Conclusion: Securing an appropriate safety margin for laparoscopic liver resection while dissecting using laparoscopic instruments was challenging without any tactile sensation by the surgeon. Moreover, no significant differences were observed in the postoperative survival of both Group I or II patients with a safety margin of ≧ 5 mm.
關鍵詞 hepatocellular carcinoma;laparoscopic liver resection;prognostic factor;safety margin
分類 Original Article

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