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第58卷 第2期 2025-3
Predatory publisher and low standard journal: An emerging problem in clinical surgery field

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第58卷 第2期 2025-3
Conflict of interest in clinical surgery: Contemporary concern in digital era

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第58卷 第2期 2025-3
Postpublication redecision and pitfalls of inadequate standards in scientific surgical journals: Important consideration in academic publication

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第58卷 第2期 2025-3
Spontaneous bilateral basal ganglia hemorrhage

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第58卷 第2期 2025-3
Academic characterization of the Formosan Journal of Surgery: A five-year bibliometric analysis

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第58卷 第2期 2025-3
Supra-sternal reconstruction for a high-hanging fruit like right subclavian artery aneurysm

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第58卷 第2期 2025-3
Operations for choledochal cysts: A 25-year experience at a tertiary care center in India

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第58卷 第2期 2025-3
A case report: Can a titanised polypropylene mesh (TiMesh) obviate a dual mesh for sandwich technique for parastomal hernias?

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第58卷 第2期 2025-3
Recurrent gallstone ileus, a deadly encounter: A case report

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第58卷 第2期 2025-3
The changes in dietary intake and tolerance for Chinese food after bariatric surgery in Taiwan

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第58卷 第2期 2025-3
Diagnostic value of trans-recto-perineal ultrasound in perianal fistula—preoperative versus intraoperative findings: A comparative cross-section study

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第58卷 第2期 2025-3
Efficacy and safety of extended-release dinalbuphine sebacate for postoperative analgesia: A systematic review and meta-analysis

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第58卷 第2期 2025-3
Dynamic changes in segmented neutrophil-to-monocyte ratio in trauma patients with stress-induced hyperglycemia: A retrospective study

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第58卷 第1期 2025-1
Ensuring authorship qualification in clinical research articles: A focus on surgical therapy studies

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第58卷 第1期 2025-1
Estimated risk for transfusion of monkeypox contaminated perioperative blood transfusion: A call to action for stronger regulations and testing protocols

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第58卷 第1期 2025-1
Insights into traumatic and crisis surgery: Implications of data analysis in conflict zones

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第58卷 第1期 2025-1
Tongue peeling as an adverse reaction with use of micronized purified flavonoid: A case report

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第58卷 第1期 2025-1
Pilonidal sinus of scrotum: A rare clinical entity

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第58卷 第1期 2025-1
Incidental autopsy finding of retiform hemangioendothelioma of the spleen

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第58卷 第1期 2025-1
Retroperitoneal laparoscopy for hydronephrosis due to multiple fibroepithelial polyps: A case series

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篇名 RUNX3 Hypermethylation in Remnant Gastric Cancer: A Preliminary Report
作者 Chih-Ming Ou Yang, Yenn-Hwei Chou, Chung-Wei Lee, Chin-Cheng Lee
卷期/出版年月 36卷6期 (2003/12)
頁次 274-278
摘要 RUNX3 (PEBP2alphaC/CBFA3/AML2) is a transcription factor downstream of the TGF β signaling pathway. RUNX3 knocked-out mice showed hyperproliferation and hyperplasia in gastric epithelium. Lack of RUNX3 expression, partly due to promoter hypermethylation, had been associated with the human gastric cancers. This study is aimed to evaluate the relationship between RUNX3 expression and human remnant gastric cancer. The methylation status of RUNX3 promoter in human remnant gastric cancer was investigated by methylation-specific restriction enzyme digestion and PCR amplification. We retrospectively reviewed the surgically removed specimen of eleven cases of remnant gastric cancer. Hypermethylation of RUNX3 in its promoter region was found in the tumor tissues of all eleven cases. Further studies are required to clarify the direct relationship between RUNX3 and remnant gastric cancer.
關鍵詞 RUNX3, remnant gastric cancer
分類 Case Report

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