台灣外科醫學會雜誌

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	第58卷第3期 2025-5 Elevating the standards of scientific editing in clinical surgery: Learning from editorial and journal role models
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	第58卷第3期 2025-5 Improving online physician evaluations for surgeons using sentiment analysis and alternative perspectives
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	第58卷第3期 2025-5 Ensuring ethical and qualified authorship: The key to trustworthiness in clinical surgery journal
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	第58卷第3期 2025-5 Artificial intelligence for academic purpose in clinic surgery: ChatGPT, Turnitin, and false positive
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	第58卷第3期 2025-5 COVID-19, COVID-19 vaccination, risk of cardiac myxoma in view of clinical surgery
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	第58卷第3期 2025-5 Eggplant deformity in penile fracture
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	第58卷第3期 2025-5 Splenectomy for Klippel-Trenaunay syndrome: Systematic review and case series
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	第58卷第3期 2025-5 Comments on “Risk factors for spinal cord injury without radiographic abnormality in trauma cases at a single trauma center”
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	第58卷第3期 2025-5 Impact of fluorescence-guided surgery on splenic preservation: A case of splenic hydatidosis
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	第58卷第3期 2025-5 Adult pancreatoblastoma presentingwith obstructive jaundice: A case report and literature review
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	第58卷第3期 2025-5 Pilonidal disease management in young adults: A retrospective analysis of practices in a single tertiary center in Bahrain
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	第58卷第3期 2025-5 Long-term comparative outcomes in patients undergoing transcatheter aortic valve implantation with self-expanding valves versus balloon-expandable valves: A retrospective observational study
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	第58卷第3期 2025-5 Comparative study between the effectiveness of Amnion-CollaGee (Collagen-Gelatin-Elastin) as a biological product wound dressing and conventional dressing on the donor site of the split-thickness skin graft in animals model (rats)
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	第58卷第3期 2025-5 Enhancing mortality Probability Model II predictive accuracy with the lethal triad in intensive care unit trauma patients: A retrospective study
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	第58卷第3期 2025-5 Dr. Shao-Wei Chen's contribution to analysis of outcomes of patients undergoing cardiac surgery and aortic disease: Big data analytics
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	第58卷第2期 2025-3 Predatory publisher and low standard journal: An emerging problem in clinical surgery field
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	第58卷第2期 2025-3 Conflict of interest in clinical surgery: Contemporary concern in digital era
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	第58卷第2期 2025-3 Postpublication redecision and pitfalls of inadequate standards in scientific surgical journals: Important consideration in academic publication
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	第58卷第2期 2025-3 Spontaneous bilateral basal ganglia hemorrhage
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	第58卷第2期 2025-3 Academic characterization of the Formosan Journal of Surgery: A five-year bibliometric analysis
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篇名	RUNX3 Hypermethylation in Remnant Gastric Cancer: A Preliminary Report
作者	Chih-Ming Ou Yang, Yenn-Hwei Chou, Chung-Wei Lee, Chin-Cheng Lee
卷期/出版年月	36卷6期 (2003/12)
頁次	274-278
摘要	RUNX3 (PEBP2alphaC/CBFA3/AML2) is a transcription factor downstream of the TGF β signaling pathway. RUNX3 knocked-out mice showed hyperproliferation and hyperplasia in gastric epithelium. Lack of RUNX3 expression, partly due to promoter hypermethylation, had been associated with the human gastric cancers. This study is aimed to evaluate the relationship between RUNX3 expression and human remnant gastric cancer. The methylation status of RUNX3 promoter in human remnant gastric cancer was investigated by methylation-specific restriction enzyme digestion and PCR amplification. We retrospectively reviewed the surgically removed specimen of eleven cases of remnant gastric cancer. Hypermethylation of RUNX3 in its promoter region was found in the tumor tissues of all eleven cases. Further studies are required to clarify the direct relationship between RUNX3 and remnant gastric cancer.
關鍵詞	RUNX3, remnant gastric cancer
分類	Case Report