篇名 |
Surgical Resection Combined with Systemic Imatinib Therapy for the Treatment of Advanced Gastrointestinal Stromal Tumor |
作者 |
Chi-Cheng Huang, Heng-Hui Lien, Ching-Shui Huang,Yuan-Chuan Sung |
卷期/出版年月 |
37卷5期 (2004/10) |
頁次 |
218-224 |
摘要 |
The results of surgical treatment of advanced gastrointestinal stromal tumor
(GIST) are poor due to low resectability and high recurrence. This situation has
been improved by the use of novel targeted molecular therapy with imatinib. For
unresectable advanced GIST, the neo-adjuvant role of imatinib relies on cytoreduction and tumor shrinkage. The operability is increased and further definite surgery is facilitated. In cases with postoperative relapse, adjuvant imatinib therapy still provides the benefits of postponing tumor progression and enabling subsequent surgeries. We report two cases of advanced GISTs treated with surgery and imatinib. The first case was an inoperable advanced GIST with peritoneal sarcomatosis which became resectable after systemic imatinib therapy for 10 months.
The second case had recurrent GIST after en bloc resection seven months earlier
and resulted in stable disease status with continuous imatinib therapy. The timing, duration and dosage of imatinib remain inconclusive and demand further studies. Lifelong follow-up of advanced GISTs is mandatory. |
關鍵詞 |
gastrointestinal stromal tumor, imatinib, surgery |
分類 |
Case Report |