中文 | ENG

第58卷 第3期 2025-5
Elevating the standards of scientific editing in clinical surgery: Learning from editorial and journal role models

.........................

第58卷 第3期 2025-5
Improving online physician evaluations for surgeons using sentiment analysis and alternative perspectives

.........................

第58卷 第3期 2025-5
Ensuring ethical and qualified authorship: The key to trustworthiness in clinical surgery journal

.........................

第58卷 第3期 2025-5
Artificial intelligence for academic purpose in clinic surgery: ChatGPT, Turnitin, and false positive

.........................

第58卷 第3期 2025-5
COVID-19, COVID-19 vaccination, risk of cardiac myxoma in view of clinical surgery

.........................

第58卷 第3期 2025-5
Eggplant deformity in penile fracture

.........................

第58卷 第3期 2025-5
Splenectomy for Klippel-Trenaunay syndrome: Systematic review and case series

.........................

第58卷 第3期 2025-5
Comments on “Risk factors for spinal cord injury without radiographic abnormality in trauma cases at a single trauma center”

.........................

第58卷 第3期 2025-5
Impact of fluorescence-guided surgery on splenic preservation: A case of splenic hydatidosis

.........................

第58卷 第3期 2025-5
Adult pancreatoblastoma presentingwith obstructive jaundice: A case report and literature review

.........................

第58卷 第3期 2025-5
Pilonidal disease management in young adults: A retrospective analysis of practices in a single tertiary center in Bahrain

.........................

第58卷 第3期 2025-5
Long-term comparative outcomes in patients undergoing transcatheter aortic valve implantation with self-expanding valves versus balloon-expandable valves: A retrospective observational study

.........................

第58卷 第3期 2025-5
Comparative study between the effectiveness of Amnion-CollaGee (Collagen-Gelatin-Elastin) as a biological product wound dressing and conventional dressing on the donor site of the split-thickness skin graft in animals model (rats)

.........................

第58卷 第3期 2025-5
Enhancing mortality Probability Model II predictive accuracy with the lethal triad in intensive care unit trauma patients: A retrospective study

.........................

第58卷 第3期 2025-5
Dr. Shao-Wei Chen's contribution to analysis of outcomes of patients undergoing cardiac surgery and aortic disease: Big data analytics

.........................

第58卷 第2期 2025-3
Predatory publisher and low standard journal: An emerging problem in clinical surgery field

.........................

第58卷 第2期 2025-3
Conflict of interest in clinical surgery: Contemporary concern in digital era

.........................

第58卷 第2期 2025-3
Postpublication redecision and pitfalls of inadequate standards in scientific surgical journals: Important consideration in academic publication

.........................

第58卷 第2期 2025-3
Spontaneous bilateral basal ganglia hemorrhage

.........................

第58卷 第2期 2025-3
Academic characterization of the Formosan Journal of Surgery: A five-year bibliometric analysis

.........................
登入帳號才能閱讀全文
 
篇名 Expression of Gastrin and its Relationship to Cell Proliferation and Oncogene Expression in Colorectal Cancer
作者 Yu-Jun He, Shuang-Wu He, Bao-Hua Liu
卷期/出版年月 38卷2期 (2005/4)
頁次 65-71
摘要 Objectives: To investigate the expression of gastrin and its relationship to the proliferative status and oncogene expression in colorectal tissues, and to explore their clinical significance. Methods: The expression of gastrin, c-myc, c-fos, rasP21 and PCNA in cancer tissue and cancer-adjacent mucosa (CAM, 3 cm and 6 cm, respectively) from 48 cases of colorectal cancer (CRC) and in normal mucosa from 10 control subjects were investigated by immunohistochemistry techniques. Argyrophilia nucleolar organizer regions (AgNORs) were determined by argyrophilia stain. Results: The positive expression of gastrin in CRC tissue was 39.6%, obviously higher than in CAM 3 cm (4.2%), CAM 6 cm (0%) and normal mucosas (0%). The positive rate of gastrin in well-differentiated adenocarcinoma was higher than that in poorly differentiated carcinoma and mucinous adenocarcinoma (P<0.05). The PCNA-LI, AgNORs count and the positive rates of c-myc, c-fos and rasP21 in CRC were obviously higher than those in CAM and normal mucosas (P<0.01). In the group of gastrin-positive expression, the PCNA-LI, AgNORs count and the positive rates of c-myc, c-fos were significantly higher than those in the group of gastrin-negative expression (P<0.05). Conclusions: Some colorectal cancer cells can produce gastrin, especially in well-differentiated adenocarcinoma. Endogenous gastrin might increase the oncogene expression of c-myc, c-fos etc and trigger the colorectal cancer cell proliferation. Gastrin may be a potential therapeutic target in the treatment of colorectal cancer.
關鍵詞 Colorectal cancer, gastrin, proliferation, oncogene
分類 Original Articles

台灣外科醫學會雜誌 © 2006 Taiwan Surgical Association All Rights Reserved
會 址:台北市南京東路五段 31 號 3 樓
電 話:(02) 2769-7845 傳 真:(02) 2746-7149 Email: journal@surgery.org.tw