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第58卷 第3期 2025-5
Elevating the standards of scientific editing in clinical surgery: Learning from editorial and journal role models

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第58卷 第3期 2025-5
Improving online physician evaluations for surgeons using sentiment analysis and alternative perspectives

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第58卷 第3期 2025-5
Ensuring ethical and qualified authorship: The key to trustworthiness in clinical surgery journal

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第58卷 第3期 2025-5
Artificial intelligence for academic purpose in clinic surgery: ChatGPT, Turnitin, and false positive

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第58卷 第3期 2025-5
COVID-19, COVID-19 vaccination, risk of cardiac myxoma in view of clinical surgery

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第58卷 第3期 2025-5
Eggplant deformity in penile fracture

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第58卷 第3期 2025-5
Splenectomy for Klippel-Trenaunay syndrome: Systematic review and case series

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第58卷 第3期 2025-5
Comments on “Risk factors for spinal cord injury without radiographic abnormality in trauma cases at a single trauma center”

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第58卷 第3期 2025-5
Impact of fluorescence-guided surgery on splenic preservation: A case of splenic hydatidosis

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第58卷 第3期 2025-5
Adult pancreatoblastoma presentingwith obstructive jaundice: A case report and literature review

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第58卷 第3期 2025-5
Pilonidal disease management in young adults: A retrospective analysis of practices in a single tertiary center in Bahrain

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第58卷 第3期 2025-5
Long-term comparative outcomes in patients undergoing transcatheter aortic valve implantation with self-expanding valves versus balloon-expandable valves: A retrospective observational study

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第58卷 第3期 2025-5
Comparative study between the effectiveness of Amnion-CollaGee (Collagen-Gelatin-Elastin) as a biological product wound dressing and conventional dressing on the donor site of the split-thickness skin graft in animals model (rats)

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第58卷 第3期 2025-5
Enhancing mortality Probability Model II predictive accuracy with the lethal triad in intensive care unit trauma patients: A retrospective study

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第58卷 第3期 2025-5
Dr. Shao-Wei Chen's contribution to analysis of outcomes of patients undergoing cardiac surgery and aortic disease: Big data analytics

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第58卷 第2期 2025-3
Predatory publisher and low standard journal: An emerging problem in clinical surgery field

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第58卷 第2期 2025-3
Conflict of interest in clinical surgery: Contemporary concern in digital era

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第58卷 第2期 2025-3
Postpublication redecision and pitfalls of inadequate standards in scientific surgical journals: Important consideration in academic publication

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第58卷 第2期 2025-3
Spontaneous bilateral basal ganglia hemorrhage

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第58卷 第2期 2025-3
Academic characterization of the Formosan Journal of Surgery: A five-year bibliometric analysis

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篇名 Smoking-induced Human Breast Cancer Formation through Induction of α9-nicotinic Acetylcholine Receptor
作者 Yuan-Soon Ho, Chia-Hwa Lee, Chih-Hsiung Wu
卷期/出版年月 44卷2期 (2011/4)
頁次 47-52
摘要 Tobacco is a substance that contains human carcinogens and may contribute to the risk for tumor formation in the lung and colon via nicotinic acetylcholine receptors (nAChRs). Nicotine receptors are a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine and are among the most wellunderstood receptors. The α4ß2 nAChR is known to exist in the central nervous system (CNS) and functions as a transmitter, whereas the α7-nAChR is a wellestablished molecule that is involved in lung cancer tumorigenesis. Previously, however, there was no direct evidence to provide a link between tobacco carcinogens and cellular molecules involved in breast tumorigenesis. Recently, two large cohort epidemiological studies undertaken in the USA and Japan have indicated that breast cancer risk is associated with both active and passive smoking. Analysis of α9- nAChR expression in clinical tumor tissues indicated that the α9-nAChR is important for tumor carcinogenesis in vivo and nicotine-induced transformation of normal human breast epithelial cells in vitro. Long-term exposure to estrogen and nicotine significantly increases α9-nAChR expression and forms a positively regulated loop and that can be blocked by several chemicals and natural compounds. In this paper, the structure and functional relationship of the nAChR will be discussed. The role of nAChR in breast cancer formation and its implication for prevention of cancer formation will also be discussed.
關鍵詞 smoking, nicotine, α9-nicotinic acetylcholine receptor, breast cancer,tumor marker
分類 Mini Review

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