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| 篇名 |
Different Modes of Clinical Progress between Parkinsonian Patients with and without Subthalamic Deep Brain Stimulation |
| 作者 |
Tomor Harnod, Shu-Hui Wen, Shin-Yuan Chen |
| 卷期/出版年月 |
44卷1期 (2011/2) |
| 頁次 |
11-17 |
| 摘要 |
Objective: Parkinson’s disease (PD) is a progressive neurodegenerative disorder.
The progress of clinical decline, typically assessed using the Unified Parkinson’s
Disease Rating Scale (UPDRS), parallels the degeneration of dopaminergic neurons.
In this study, we retrospectively analyzed differences in the rate of UPDRS score
decline between patients who underwent and who did not undergo subthalamic deep
brain stimulation (STN-DBS).
Methods: Thirty-two patients (22 men and 10 women) with advanced PD were
included in pre-surgical analysis. Twenty-seven patients (18 males and 9 females) out
of 32 patients completed post-surgical evaluations. Core assessments were made for
every patient. During post-surgical examinations, UPDRS scores were recorded
during DBS-on and DBS-off periods (both were determined during the levodopa-off
period). The effect of STN-DBS was determined by comparing the DBS-on and DBSoff
UPDRS scores. Repeated measure analysis of variance (ANOVA) was performed
for a comparison between the UPDRS scores in patients when with DBS-on and
when with DBS-off.
Results: Mean follow-up was 23.4 months after the initiation of STN-DBS. UPDRS
scores during DBS-on were significantly lower than scores during DBS-off (43.3±3.2
vs 71.4±3.8, P=0.03). There was a significant effect of patient age on levodopa-off
UPDRS scores over time (P=0.01). There was a borderline significant effect (P=0.06)
of PD duration on levodopa-off UPDRS scores.
Conclusions: STN-DBS does not restore functional loss of patients with PD, but
there are differences in clinical progress between patients with and those without
STN-DBS. |
| 關鍵詞 |
clinical progress, deep brain stimulation, Parkinson’s disease |
| 分類 |
Original Article |
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