台灣外科醫學會雜誌

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篇名	Distribution of Hypoxia-Inducible Factor-1α and Bcl-2 —A Study of Varicose Veins by Confocal Microscopy
作者	Chin-Cheng Yi, Wen-Kai Yang, Jane-Dar Lee
卷期/出版年月	43卷5期 (2010/10)
頁次	229-235
摘要	Objective: The tissue hypoxia caused by chronic venous insufficiency and blood stasis is the etiology of varicose vein formation. Bcl-2 (anti-apoptotic protein) reduces apoptosis may contribute to the dilated and thickened walls of the diseased vessels. We studied the distribution and relationship of hypoxia-inducible factor-1 α (HIF-1α ) and Bcl-2 in varicose veins by confocal microscopy. Methods: This study consisted of examination of 1cm venous segments (hypertrophic type) from 12 patients obtained during conventional stripping surgery for the varicose saphenous vein in the calf muscle region. All vascular specimens were studied for HIF-1α and Bcl-2 by immunohistochemical stain and confocal laser scanning microscopy. Results: In varicose veins, the immunohistochemical staining of both HIF-1α and Bcl-2 showed strong immunostaining in the hypertrophic smooth muscle layer. In further study, prominent HIF-1α distribution in the muscle layer and Bcl-2 protein deposition in the endothelial layer were demonstrated under confocal laser scanning microscopy. Conclusions: These results revealed prominent HIF-1α and Bcl-2 distribution in the muscle layer with co-localization, and Bcl-2 overexpression in the endothelial layer of varicose vein vessels under confocal microscopy.
關鍵詞	HIF-1α , Bcl-2, varicose vein, confocal microscopy
分類	Original Article