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篇名 Inflammation-related Biomarkers in Esophageal Squamous Cell Carcinoma
作者 Liang-Shun Wang
卷期/出版年月 43卷5期 (2010/10)
頁次 211-223
摘要 Increasing evidences have expanded the concept that inflammation is a critical component of tumor progression and therapeutic resistance in most types of malignancy. The mediators and cellular effectors of inflammation are important constituents of tumor microenvironment. ‘Smoldering’ inflammation in the tumor microenvironment induces many tumor-promoting effects, including fostering of cell proliferation and survival, promotion of angiogenesis, tumor invasion/metastasis, and evasion of host immunosurveillance. The molecular pathways of the cancerrelated inflammation are now being unraveled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment. The current clinicopathological staging system for esophageal squamous cell carcinoma (ESCC) is inadequate for predicting the therapeutic response and prognosis. It is believed that multiple intrinsic factors in making the difference of therapeutic responses or outcomes exist. An association of chronic inflammation in the esophagus with tumor initiation and promotion indicates that an understanding on the clinical implications and the pathophysiological regulation of the inflammation-related biomarkers is quite important in prognostic prediction and improvement of therapeutic outcomes, or innovative therapeutic strategy, for ESCC patients. In an attempt to broaden our knowledge, we have, in this review article, also summarized the common mechanisms associated with inflammation-related biomarkers identified in ESCC.
關鍵詞 inflammation, biomarker, chemokine, cytokine, esophageal cancer
分類 Review

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