台灣外科醫學會雜誌

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	第58卷第1期 2025-1 Ensuring authorship qualification in clinical research articles: A focus on surgical therapy studies
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	第58卷第1期 2025-1 Estimated risk for transfusion of monkeypox contaminated perioperative blood transfusion: A call to action for stronger regulations and testing protocols
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	第58卷第1期 2025-1 Insights into traumatic and crisis surgery: Implications of data analysis in conflict zones
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	第58卷第1期 2025-1 Tongue peeling as an adverse reaction with use of micronized purified flavonoid: A case report
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	第58卷第1期 2025-1 Pilonidal sinus of scrotum: A rare clinical entity
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	第58卷第1期 2025-1 Incidental autopsy finding of retiform hemangioendothelioma of the spleen
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	第58卷第1期 2025-1 Retroperitoneal laparoscopy for hydronephrosis due to multiple fibroepithelial polyps: A case series
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	第58卷第1期 2025-1 Case reports of type 1 cystic biliary atresia—A rare variant of biliary atresia alongwith reviewof literature
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	第58卷第1期 2025-1 The predictors of intraoperative surgical expenses in liver resection for hepatocellular carcinoma
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	第58卷第1期 2025-1 Intracorporeal anastomosis versus extracorporeal anastomosis following laparoscopic right hemicolectomy: Surgical outcomes of a single-center observational study
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	第58卷第1期 2025-1 Quality of life and spiritual health in motorcycle accident survivors: An analysis using the SF-36 Questionnaire and Spiritual Scale
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	第58卷第1期 2025-1 Plastin 3 expression in circulating tumor cells as a predictor of cancer status in patients with prostate cancer
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	第57卷第6期 2024-11 Emerging robot-guided techniques in endodontic microsurgery
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	第57卷第6期 2024-11 Management of subcapsular hematoma after living donor liver transplant
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	第57卷第6期 2024-11 Urethral pseudodiverticulum with left-sided nonfunctioning kidney: Case report
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	第57卷第6期 2024-11 Strategy to minimize surgical defect of dermatofi brosarcoma protuberans
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	第57卷第6期 2024-11 Rapunzel syndrome—An uncommon disease with varied common presentations
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	第57卷第6期 2024-11 Minimally invasive approaches to management of acute necrotizing pancreatitis
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	第57卷第6期 2024-11 Innovative surgical technique: Addressing ethical concerns
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	第57卷第6期 2024-11 Emergency surgery and HIV screening, clinical or universal scenarios?
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篇名	Pathophysiological Factors Contributing to Keloid Formation
作者	Fa-Lai Yeh
卷期/出版年月	43卷1期 (2010/2)
頁次	1-6
摘要	Keloid formation occurs following an abnormal wound healing. It represents a significant therapeutic challenge to physicians. A better understanding of the pathophysiologic processes underlying keloid formation may help in the development of more successful therapeutic interventions. This article delineates current information on the pathogenesis of keloids. Results reported in the literature and obtained from our studies showed that keloid-derived fibroblasts demonstrated a higher growth potential and produced higher levels of procollagen than those produced by control-derived fibroblasts. In addition, our results also showed a decreased production of inflammatory mediators of MCP-1, PGE2, MMP-1, MMP-2 and TIMP-2 by keloid-derived fibroblasts as compared with normal skin-derived fibroblasts. Furthermore, current literature also indicates that the growth factor TGF-ß is overproduced and poorly regulated in keloid tissue. These alterations in the wound healing process may result in delayed and prolonged activation of injuryinduced inflammation as well as imbalance in the extracellular matrix formation and degradation that may contribute to excess deposition of collagen in skin lesions and lead to keloid formation.
關鍵詞	keloid, pathophysiology
分類	Mini Review