台灣外科醫學會雜誌

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篇名	Pathophysiological Factors Contributing to Keloid Formation
作者	Fa-Lai Yeh
卷期/出版年月	43卷1期 (2010/2)
頁次	1-6
摘要	Keloid formation occurs following an abnormal wound healing. It represents a significant therapeutic challenge to physicians. A better understanding of the pathophysiologic processes underlying keloid formation may help in the development of more successful therapeutic interventions. This article delineates current information on the pathogenesis of keloids. Results reported in the literature and obtained from our studies showed that keloid-derived fibroblasts demonstrated a higher growth potential and produced higher levels of procollagen than those produced by control-derived fibroblasts. In addition, our results also showed a decreased production of inflammatory mediators of MCP-1, PGE2, MMP-1, MMP-2 and TIMP-2 by keloid-derived fibroblasts as compared with normal skin-derived fibroblasts. Furthermore, current literature also indicates that the growth factor TGF-ß is overproduced and poorly regulated in keloid tissue. These alterations in the wound healing process may result in delayed and prolonged activation of injuryinduced inflammation as well as imbalance in the extracellular matrix formation and degradation that may contribute to excess deposition of collagen in skin lesions and lead to keloid formation.
關鍵詞	keloid, pathophysiology
分類	Mini Review