| 篇名 |
Resection Margin in Preventing the Intrahepatic Recurrence after Resection of Hepatocellular Carcinoma |
| 作者 |
Chao-Chin Yu, Mei-Du Yang, Chen-Teng Wu, Long-Bin Jeng |
| 卷期/出版年月 |
40卷6期 (2007/12) |
| 頁次 |
236-242 |
| 摘要 |
Objectives: The extent of the liver resection margin (RM) for hepatocellular
carcinoma (HCC) remains controversial. The aim of this study is to re-evaluate the optimal extent of resection.
Methods: After exclusion of extrahepatic recurrence (n=12) or RM=0 cm (n=7), a
retrospective review of 202 patients who underwent curative liver resection for
primary HCC from May 1995 to Dec 2003 was conducted. These patients were
divided into 4 groups according to the RM as < 0.5 cm, 0.5-0.99 cm, 1-1.99 cm, and ≥2 cm, respectively. Then the same patients were re-divided into 2 groups as RM < 1 cm and ≥ 1 cm. We also analyzed the relationship of the 2 groups with RM < 0.5 cm and ≥ 0.5 cm from the same 202 patients. The difference of intrahepatic recurrence rate and patient survival rate were evaluated by the Kaplan-Meier method and compared by the log-rank test.
Results: Both the RM among the 4 groups and RM < 1 cm vs. ≥ 1 cm were not a
significant factor related to patient survival or to the intrahepatic recurrence. Patients with a tumor RM less than 0.5 cm had a poorer prognosis on intrahepatic recurrence (n=34, median value=8.1 months) than those with a RM greater than or equal to 0.5 cm (n=168, median value=18.6 months) (P=0.0371).
Conclusions: RM of greater or equal to 0.5 cm is adequate with regard to the
prevention of intrahepatic recurrence after resection of HCC. |
| 關鍵詞 |
liver resection, resection margin, hepatocellular carcinoma, intrahepatic |
| 分類 |
Original Article |
