台灣外科醫學會雜誌

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	第57卷第6期 2024-11 Emerging robot-guided techniques in endodontic microsurgery
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	第57卷第6期 2024-11 Management of subcapsular hematoma after living donor liver transplant
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	第57卷第6期 2024-11 Urethral pseudodiverticulum with left-sided nonfunctioning kidney: Case report
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	第57卷第6期 2024-11 Strategy to minimize surgical defect of dermatofi brosarcoma protuberans
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	第57卷第6期 2024-11 Rapunzel syndrome—An uncommon disease with varied common presentations
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	第57卷第6期 2024-11 Minimally invasive approaches to management of acute necrotizing pancreatitis
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	第57卷第6期 2024-11 Innovative surgical technique: Addressing ethical concerns
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	第57卷第6期 2024-11 Emergency surgery and HIV screening, clinical or universal scenarios?
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	第57卷第6期 2024-11 High mortality rates associated with parainfl uenza virus, not metapneumovirus, infections in lung transplant recipients: A retrospective observation
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	第57卷第6期 2024-11 Predatory clinical surgery journal, rescinding the decision to accept submitted article and unjustifi ed rejection and unprofessional conduct
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	第57卷第6期 2024-11 Sacrifi cial of unilateral vertebral artery for fragment removal following vertebral artery injury by air rif le pellet gunshot: A case report
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	第57卷第6期 2024-11 Evaluation of three-dimensional reconstruction technology in precision hepatectomy for primary liver cancer
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	第57卷第6期 2024-11 Exploring the seasonal variation of anorectal disease: A comprehensive study
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	第57卷第6期 2024-11 Efficacy of the minimal-invasive vacuum-assisted biopsy under direct visualization with ultrasound for impalpable breast lesions in Taiwanese female: A retrospective case-control study
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	第57卷第6期 2024-11 Computed tomography on the 5th postoperative day helps distinguish grade C from grade B pancreatic fi stula after pancreaticoduodenectomy for periampullary cancer
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	第57卷第6期 2024-11 Pressurized intraperitoneal aerosol chemotherapy (PIPAC): Why it will transform cancer surgery
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	第57卷第5期 2024-9 Evaluating the pros and cons of anonymous commenting on PubPeer
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	第57卷第5期 2024-9 Infected urachal cyst with urethral stricture disease presenting with intraperitoneal perforation of cyst and pyoperitoneum
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	第57卷第5期 2024-9 COVID-19 vaccination and acute cholecystitis: A rare but important clinical problem
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	第57卷第5期 2024-9 Hobnail-shaped primary prostatic urethral calculus due to urethral stricture disease
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篇名	Genetic Variants Susceptibility to Breast Cancer
作者	Huan-Ming Hsu
卷期/出版年月	42卷6期 (2009/12)
頁次	299-303
摘要	Breast cancer is currently the leading cause of common women cancers in Taiwan. Familial breast cancer accounts for only 5-10% of all breast cancers. The breast cancer risk is likely to be explained by a polygenic model where breast cancer susceptibility is conferred by a large number of low-penetrance alleles of genes involving DNA repair pathway. The exposure to estrogen predisposes to DNA damage and mutation to become the modifying factor of breast cancer risk. The metabolites of estrogen cause DNA damage resulting in genomic instability. The subtle defect of the DNA repair pathway genes has no complete capacity for DNA repair. The accumulated DNA defects combined with environmental estrogen exposure predispose to breast tumorigenesis.
關鍵詞	breast cancer, polymorphic variant
分類	Mini Review