台灣外科醫學會雜誌

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	第58卷第1期 2025-1 Ensuring authorship qualification in clinical research articles: A focus on surgical therapy studies
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	第58卷第1期 2025-1 Estimated risk for transfusion of monkeypox contaminated perioperative blood transfusion: A call to action for stronger regulations and testing protocols
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	第58卷第1期 2025-1 Insights into traumatic and crisis surgery: Implications of data analysis in conflict zones
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	第58卷第1期 2025-1 Tongue peeling as an adverse reaction with use of micronized purified flavonoid: A case report
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	第58卷第1期 2025-1 Pilonidal sinus of scrotum: A rare clinical entity
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	第58卷第1期 2025-1 Incidental autopsy finding of retiform hemangioendothelioma of the spleen
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	第58卷第1期 2025-1 Retroperitoneal laparoscopy for hydronephrosis due to multiple fibroepithelial polyps: A case series
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	第58卷第1期 2025-1 Case reports of type 1 cystic biliary atresia—A rare variant of biliary atresia alongwith reviewof literature
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	第58卷第1期 2025-1 The predictors of intraoperative surgical expenses in liver resection for hepatocellular carcinoma
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	第58卷第1期 2025-1 Intracorporeal anastomosis versus extracorporeal anastomosis following laparoscopic right hemicolectomy: Surgical outcomes of a single-center observational study
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	第58卷第1期 2025-1 Quality of life and spiritual health in motorcycle accident survivors: An analysis using the SF-36 Questionnaire and Spiritual Scale
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	第58卷第1期 2025-1 Plastin 3 expression in circulating tumor cells as a predictor of cancer status in patients with prostate cancer
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	第57卷第6期 2024-11 Emerging robot-guided techniques in endodontic microsurgery
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	第57卷第6期 2024-11 Management of subcapsular hematoma after living donor liver transplant
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	第57卷第6期 2024-11 Urethral pseudodiverticulum with left-sided nonfunctioning kidney: Case report
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	第57卷第6期 2024-11 Strategy to minimize surgical defect of dermatofi brosarcoma protuberans
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	第57卷第6期 2024-11 Rapunzel syndrome—An uncommon disease with varied common presentations
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	第57卷第6期 2024-11 Minimally invasive approaches to management of acute necrotizing pancreatitis
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	第57卷第6期 2024-11 Innovative surgical technique: Addressing ethical concerns
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	第57卷第6期 2024-11 Emergency surgery and HIV screening, clinical or universal scenarios?
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篇名	Genetic Variants Susceptibility to Breast Cancer
作者	Huan-Ming Hsu
卷期/出版年月	42卷6期 (2009/12)
頁次	299-303
摘要	Breast cancer is currently the leading cause of common women cancers in Taiwan. Familial breast cancer accounts for only 5-10% of all breast cancers. The breast cancer risk is likely to be explained by a polygenic model where breast cancer susceptibility is conferred by a large number of low-penetrance alleles of genes involving DNA repair pathway. The exposure to estrogen predisposes to DNA damage and mutation to become the modifying factor of breast cancer risk. The metabolites of estrogen cause DNA damage resulting in genomic instability. The subtle defect of the DNA repair pathway genes has no complete capacity for DNA repair. The accumulated DNA defects combined with environmental estrogen exposure predispose to breast tumorigenesis.
關鍵詞	breast cancer, polymorphic variant
分類	Mini Review