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第58卷 第2期 2025-3
Predatory publisher and low standard journal: An emerging problem in clinical surgery field

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Conflict of interest in clinical surgery: Contemporary concern in digital era

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Spontaneous bilateral basal ganglia hemorrhage

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Academic characterization of the Formosan Journal of Surgery: A five-year bibliometric analysis

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Supra-sternal reconstruction for a high-hanging fruit like right subclavian artery aneurysm

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Operations for choledochal cysts: A 25-year experience at a tertiary care center in India

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Recurrent gallstone ileus, a deadly encounter: A case report

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The changes in dietary intake and tolerance for Chinese food after bariatric surgery in Taiwan

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Diagnostic value of trans-recto-perineal ultrasound in perianal fistula—preoperative versus intraoperative findings: A comparative cross-section study

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Dynamic changes in segmented neutrophil-to-monocyte ratio in trauma patients with stress-induced hyperglycemia: A retrospective study

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Ensuring authorship qualification in clinical research articles: A focus on surgical therapy studies

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Insights into traumatic and crisis surgery: Implications of data analysis in conflict zones

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Pilonidal sinus of scrotum: A rare clinical entity

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Incidental autopsy finding of retiform hemangioendothelioma of the spleen

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篇名 Salt-modified Polycaprolactone Collagen Scaffold for
作者 Dah-Shyong Yu, Hong-I Chen, Sun-Yran Chang, Cheng-Ping Ma
卷期/出版年月 40卷6期 (2007/12)
頁次 229-235
摘要 Objective: A synthetic polymer, polycaprolactone (PCL) scaffold, was designed in order to enhance its cell affinity, porosity, and biocompatibility in performing tissue engineering. Methods: The salt-modified PCL-collagen copolymer was synthesized by a dioxane polymerization method with different weight ratio of salt and coated by collagen. Scaffolds with various thickness were synthesized and dried in a Teflon plate. The characteristics of these synthetic scaffolds were analyzed with regard to morphological, biomechanical and biocompatibilitic properties. Cellular growth and morphology were observed under an inverted microscope and a scanning electron microscope. The proliferation rate of cultured cells was determined using a microculture tetrazolium method. The confirmation of cultured cells was performed through several aspects using specific marker stains. The biodegradability of scaffolds was examined after long term soaking in the medium. Results: The copolymer was very flexible and elastic, and they could maintain their high elasticity under cyclic mechanical strain conditions. The highly porous scaffold withstood for an initial 1 week without any deformation and sustained for at least 3 weeks in culture media without prominent degradation. When 1:4 wt% salt was used to modify the PCL-collagen scaffold, the amount of adhesion of the fibroblasts and cultured urothelial cells on the scaffolds dramatically increased when compared with the control PLC alone. The taking and growth of cells were observed at 2 days interval and continued in proliferation of cells for 3 weeks. The cell adhesion and proliferation on the scaffolds of various pore-size were increased with increasing pore size. Conclusions: These results indicate that the salt-modified PCL-collagen copolymer scaffolds are feasible for urothelial proliferation. The improvement may be helpful for the extensive applications of PCL-salt-collagen copolymer scaffold in urological tissue engineering.
關鍵詞 Scaffold, salt modified PCL-collagen copolymer, urothelial cells, tissue
分類 Original Article

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