| 摘要 |
A personal history of breast cancer is a well established risk factor for subsequent
new primary breast tumors. The annual incidence is 0.5-1.0%, 2 to 6 times higher
than the incidence of normal women in Western countries to develop primary breast
cancer. The 10-year cumulative incidence is around 6-11%. The early age of
diagnosis, family history of breast cancer, estrogen receptor status, lobular
carcinoma histology, previous radiotherapy and a lack of tamoxifen treatment are
thought to be risk factors of bilateral breast cancer. Our investigation also shows
menopause, invasive lobular carcinoma, and previous chemotherapy and/or
radiotherapy to be risk factors of developing bilateral breast cancer, and tamoxifen
therapy to be a protective factor. Regarding prognosis, previous studies comparing
survivals between Western women with bilateral and those with unilateral breast
cancer have yielded inconsistent results. However, recent reports from a large
Sweden cohort and our study have shown that women with metachronous bilateral
breast cancer had a worse survival as compared with those with unilateral breast
cancer and synchronous bilateral breast cancer. Taiwanese women had a poorer
survival than Swedish women. Chemotherapy showed no significant effects on
survival in Taiwanese women. |
