| 篇名 |
Plastin 3 expression in circulating tumor cells as a predictor of cancer status in patients with prostate cancer |
| 作者 |
Meng-Hung Shih , Tai-Lung Cha, Sheng-TangWu, EnMeng, Chih-Wei Tsao, Chien-Chang Kao, Chin-Li Chen, Yu-Ching Juho, Hui-Kung Ting, Guang-Huan Sun, Sun-Yran Chang, Dah-Shyong Yu, Ming-Hsin Yang |
| 卷期/出版年月 |
58卷1期 (2025/1) |
| 頁次 |
1-5 |
| 摘要 |
Background: Prostate cancer (PCa) is the most common cancer among men worldwide. The aim of the study is to identify the role of plastin 3 (PLS3) expression in circulating tumor cells (CTCs) of early stage PCa.
MaterialsandMethods: CTCs were collected from23 PCa patients based on cell surfacemarkers targeting PCa by V-BioChip. Condition of Plastin 3 expression and correlations to the PCa were also analyzed.
Results: Of the 23 patients with PCa, total CTCs (CK+ or PLS3+) were found in 11 patients and PLS3+ CTCs were detected in 10 patients. When the cohort was stratified by risk group, 90% of the high-risk patients were found to have PLS3+ circulating tumor cells (9/10 patients). However, only 15.4% of low/intermediate-risk patients had PLS3+ circulating tumor cells (2/13 patients). The number of PLS3+ CTCs was higher in the high-risk group.
Conclusions: The expression of PLS3 in CTCs is associated with PCa risk. Further study of PLS3+ CTCs for prognosis prediction is required for clinical application in PCa patients. |
| 關鍵詞 |
CTCs; Prostate cancer; PLS3; Risk stratification Abbreviations: CTCs, circulating tumor cells; PLS3, plastin 3; PCa, prostate cancer; PSA, prostate-specific antigen; PLS2, plastin 2; OS, overall survival; DFS, disease-free survival |
| 分類 |
Original Article |
