| 摘要 |
Background: Clinically relevant postoperative pancreatic fistula (CRPF) is considered the most dangerous morbidity associated with pancreaticoduodenectomy (PD). The purpose of this study was to evaluate the risk factors and to construct a predicted model for CRPF after PD.
Materials andMethods: Consecutive patients who underwent pancreaticoduodenectomy between August 2021 and October 2023 at Cho Ray Hospital and UniversityMedical Center were included in amulticenter cohort research.Multivariate logistic regression analyses were used to identify the risk factors of CRPF, and a nomogramwas built based on these factors. The value of the nomogramin predicting
CRPF was evaluated using the area under the receiver operating characteristic (ROC) curve.
Results: There were 183 eligible patients in this study (mean age: 57.5 ± 12.6 years; 101males), and the prevalence of CRPFwas 13.7% overall. Multivariate analyses showed that 4 risk factors related to CRPF, including preoperative serum albumin <3.5 g/dL, body mass index (BMI) ≥25 kg/m2, soft texture of the pancreas and estimated blood loss ≥400 mL were prognostic factors for CRPF (P < 0.05). We built a nomogram based on 4 variables to predict CRPF, and the area under the ROC curve for this nomogram was 0.855 (95% CI: 0.768–0.933).
Conclusions: Nomogram developed from4 risk factors shows good performance to predict CRPF after PD. The clinical findings of this study will help surgeons identify perioperative risk factors for high-risk patients with pancreatic fistula who should be managed differently from other patients.
Clinical Trial Registry: ClinicalTrials.gov NCT05017207.
StatementofSignificance:We successfully developed a nomogram to predict the risk of pancreatic fistula using 4 perioperative factors. By incorporating these risk factors into clinical practice, surgeons can develop appropriate treatment plans and interventions for highrisk patient populations, potentially reducing the morbidity associated with CRPF. |
