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第58卷 第3期 2025-5
Elevating the standards of scientific editing in clinical surgery: Learning from editorial and journal role models

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第58卷 第3期 2025-5
Improving online physician evaluations for surgeons using sentiment analysis and alternative perspectives

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第58卷 第3期 2025-5
Ensuring ethical and qualified authorship: The key to trustworthiness in clinical surgery journal

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第58卷 第3期 2025-5
Artificial intelligence for academic purpose in clinic surgery: ChatGPT, Turnitin, and false positive

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第58卷 第3期 2025-5
COVID-19, COVID-19 vaccination, risk of cardiac myxoma in view of clinical surgery

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第58卷 第3期 2025-5
Eggplant deformity in penile fracture

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第58卷 第3期 2025-5
Splenectomy for Klippel-Trenaunay syndrome: Systematic review and case series

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第58卷 第3期 2025-5
Comments on “Risk factors for spinal cord injury without radiographic abnormality in trauma cases at a single trauma center”

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第58卷 第3期 2025-5
Impact of fluorescence-guided surgery on splenic preservation: A case of splenic hydatidosis

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第58卷 第3期 2025-5
Adult pancreatoblastoma presentingwith obstructive jaundice: A case report and literature review

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第58卷 第3期 2025-5
Pilonidal disease management in young adults: A retrospective analysis of practices in a single tertiary center in Bahrain

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第58卷 第3期 2025-5
Long-term comparative outcomes in patients undergoing transcatheter aortic valve implantation with self-expanding valves versus balloon-expandable valves: A retrospective observational study

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第58卷 第3期 2025-5
Comparative study between the effectiveness of Amnion-CollaGee (Collagen-Gelatin-Elastin) as a biological product wound dressing and conventional dressing on the donor site of the split-thickness skin graft in animals model (rats)

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第58卷 第3期 2025-5
Enhancing mortality Probability Model II predictive accuracy with the lethal triad in intensive care unit trauma patients: A retrospective study

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第58卷 第3期 2025-5
Dr. Shao-Wei Chen's contribution to analysis of outcomes of patients undergoing cardiac surgery and aortic disease: Big data analytics

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第58卷 第2期 2025-3
Predatory publisher and low standard journal: An emerging problem in clinical surgery field

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第58卷 第2期 2025-3
Conflict of interest in clinical surgery: Contemporary concern in digital era

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第58卷 第2期 2025-3
Postpublication redecision and pitfalls of inadequate standards in scientific surgical journals: Important consideration in academic publication

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第58卷 第2期 2025-3
Spontaneous bilateral basal ganglia hemorrhage

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第58卷 第2期 2025-3
Academic characterization of the Formosan Journal of Surgery: A five-year bibliometric analysis

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篇名 Lycopene exerts cytotoxic effects by mitochondrial reactive oxygen species–induced apoptosis in glioblastoma multiforme
作者 Huey-Jiun Ko, Yu-Feng Su, Joon-KhimLoh, Cheng Yu Tsai
卷期/出版年月 57卷5期 (2024/9)
頁次 181-188
摘要 Background: Glioblastoma multiforme (GBM) faces challenges with standard treatments, prompting exploration into alternative approaches. Reactive oxygen species (ROS) are implicated in cancer development,making antioxidants from natural sources, such as lycopene in tomatoes, promising candidates. This study aimed to assess the effectiveness of lycopene in GBM. MaterialsandMethods: The PAMPA-BBB assay predicted lycopene penetration. After treating GBM8401 and T98GGBMcellswith lycopene, flow cytometry assessed cell cycle and apoptosis, while the CCK-8 assay measured antiproliferative efficacy. Colony formation assay examined cell growth, and intracellular andmitochondrial ROS levels were quantified.Western blot analyzed protein levels of p-ERK/ ERK, p53, and cyclin-related proteins. Results: Our results demonstrated lycopene penetration across the blood-brain barrier and its induction of apoptosis, inhibiting proliferation in GBM8401 and T98G GBMcells. In addition, lycopene promoted p53 upregulation and suppressed cyclins B and cyclin D, leading to cell cycle arrest through ROS-activated ERK pathways. Conclusions: In conclusion, our study focused on lycopene’s potential in GBMtreatment, revealing its ability to induce apoptosis, inhibit proliferation, and regulate the cell cycle through ROS-activated ERK pathways. These findings suggest lycopene as a promising candidate for preventing and treating GBM by targeting ROS-induced cell proliferation, paving the way for future research.
關鍵詞 GBM; ROS; Lycopene; Antioxidants; ERK pathways
分類 Original Article

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