| 摘要 |
Background: Invasive carcinoma or dysplasia (biliary intraepithelial neoplasia [BilIN]) is often found in the surgical stumps of biliary tract
cancer. We investigated whether the presence of BilIN at the surgical margin is a risk factor for recurrence.
Materials andMethods: Seventy-five consecutive patients who underwent curative resection for biliary tract cancer were included in
this study. We retrospectively evaluated the surgicalmargin status (negative, BilIN, or positive) and analyzed the postoperative disease recurrence
rate and recurrence pattern by the status.
Results: The disease-free survival rate was significantly worse in the positive margin group than in the negative margin group (11 vs
18months, P = 0.027). There were no statistical differences between the BilIN-positive group and the other two groups. In themultivariate
analysis, infiltrative growth c (hazard ratio [HR], 3.348; 95% confidence interval [CI], 1.368–8.195; P = 0.008) and pathological exhumed
margin (HR, 2.670; 95%CI, 1.097–6.495; P = 0.030) were independent recurrence factors. Themargin status of BilIN was not associated
with recurrence (HR, 0.867; 95% CI, 0.491–2.946; P = 0.687).
Conclusions: The BilIN component at the surgical margin was not associated with short-term recurrence, but the pathological exhumed
margin positive and infiltrative growth c were. Infiltrative growth c may be a potential predictive factor for recurrence. |
