| 摘要 |
Intravenous administration of superoxide dismutase (SOD) can scavenge oxygen radicals, inhibit lipid peroxidation and accelerate burn wound healing in burn patients. However, the effect of topical SOD gel used over the burn wounds has not been well documented. Cu, Zn-SOD gel, 0.1 %[ SOD ( +) gel ] and the placebo [ SOD （一） gel ] were applied over two areas of second degree burn wounds, 10× 10 cm2 each in size, twice a day for seven days following burn, in a double-lind method. The percentage of healed area (re-epithelialization) of burn wound was calculated and recorded from the 5th to the 14th days in 10 patients who had suffered from second to third degree burn, 30% to 90% total body surface area (TBSA). There was significant difference in the mean percentage of healed area between the two groups from the 5th to the 14th days following burn injury (p<0.01, by paired Students' t test). The mean percentage of healed area in SOD ( +) and SOD （一） groups the seventh day after topical application of the gel were 61.3 ± 21.1 % , and 40.8 ± 17 .6 % respectively, a significant statistic difference (p<0.0005 by paired Students' t test). Topical use of Cu, Zn-SOD gel, 0.1 %, twice a day from the first to the seventh days after burn injury over the wound significantly accelerated re-epithelialization and wound healing clinically. |
