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第58卷 第3期 2025-5
Elevating the standards of scientific editing in clinical surgery: Learning from editorial and journal role models

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Improving online physician evaluations for surgeons using sentiment analysis and alternative perspectives

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Artificial intelligence for academic purpose in clinic surgery: ChatGPT, Turnitin, and false positive

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COVID-19, COVID-19 vaccination, risk of cardiac myxoma in view of clinical surgery

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Eggplant deformity in penile fracture

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Splenectomy for Klippel-Trenaunay syndrome: Systematic review and case series

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Comments on “Risk factors for spinal cord injury without radiographic abnormality in trauma cases at a single trauma center”

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Impact of fluorescence-guided surgery on splenic preservation: A case of splenic hydatidosis

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Adult pancreatoblastoma presentingwith obstructive jaundice: A case report and literature review

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Pilonidal disease management in young adults: A retrospective analysis of practices in a single tertiary center in Bahrain

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Long-term comparative outcomes in patients undergoing transcatheter aortic valve implantation with self-expanding valves versus balloon-expandable valves: A retrospective observational study

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Comparative study between the effectiveness of Amnion-CollaGee (Collagen-Gelatin-Elastin) as a biological product wound dressing and conventional dressing on the donor site of the split-thickness skin graft in animals model (rats)

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Enhancing mortality Probability Model II predictive accuracy with the lethal triad in intensive care unit trauma patients: A retrospective study

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Dr. Shao-Wei Chen's contribution to analysis of outcomes of patients undergoing cardiac surgery and aortic disease: Big data analytics

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第58卷 第2期 2025-3
Predatory publisher and low standard journal: An emerging problem in clinical surgery field

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第58卷 第2期 2025-3
Conflict of interest in clinical surgery: Contemporary concern in digital era

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Postpublication redecision and pitfalls of inadequate standards in scientific surgical journals: Important consideration in academic publication

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Spontaneous bilateral basal ganglia hemorrhage

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Academic characterization of the Formosan Journal of Surgery: A five-year bibliometric analysis

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篇名 Werum Amino Acid Pattern in Total Parenteral Nutrition with Essential Amino Acids as the Sole Nitrogen Source
作者 Jenq-Chang Lee, Hong-Shiee Lai, Wei-Jao Chen, Shan-Tair Wang, Chih-Jen Chang
卷期/出版年月 28卷5期 (1995/10)
頁次 341-348
摘要 Hyperammonemic encephalopathy was found in every rat given total parenteral nutrition (TPN) with essential amino acids (EAA) as the only source of nitrogen in a previous experiment here. The amino acid pattern in the serum was checked to determine its mechanism. Forty male Long-Evan rats were divided into five equal groups receiving feed αd libitum or with different formulae of TPN. The serum ammonia levels of the rats given TPN with EAA as the only source of nitrogen were significantly higher than that of the control group given food αd libitum and groups given TPN for the same number of days but with mixed amino acids (MAA)as the source of nitrogen. The mean concentration of essential and nonessential amino acids of the groups given TPN with EAA was not distinct from that of the corresponding groups given TPN with MAA, except for the mean concentrations of some urea-cycle amino acids such as citrulline and ornithine, and glycine in the serum. The mean concentration of arginine in serum of the TPN with EAA groups was not lower than that of the corresponding groups given TPN with MAA and the control group. The mean serum level of other amino acids in the urea cycle such as ornithine or citrulline, was lower in the groups given TPN with EAA than that of groups given TPN with MAA and the control group, specially the three-day group. It was concluded that TPN using EAA exclusively as the source of nitrogen resulted in hyperammonemia. The deficiency of arginine in the formula failed to account for the hyperammonemia observed. Deficiencies of citrulline and ornithine resulting from inhibition of arginosuccinate synthetase may play a part, but the mechanism may be much more complicated. EAAs are to be avoided as the only source of nitrogen when TPN is indicated and if their use is necessary, the serum ammonia level should be tested frequently. If the level remains elevated or if toxicity develops, consideration should be given to an alternative fluid.
關鍵詞 total parenteral nutrition, essential amino acid, urea cycle, mixed amino acids, hyperammonemia.
分類 Original Article

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