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| 篇名 |
Limited Myocardial Protective Effect of Leukocyte-depleted Blood Cardioplegia in Mitral Valve Surgery |
| 作者 |
Chia-Chan Wu, Tzu-Yu Lin, Kuan-Ming Chiu, Shu-Hsun Chu |
| 卷期/出版年月 |
41卷5期 (2008/10) |
| 頁次 |
203-208 |
| 摘要 |
Objective: Leukocytes are the main effectors to cause reperfusion injury in patients
undergoing heart surgery, which may result in myocardial damage and unfavorable
outcome. The aim of this study was to investigate whether leukocyte depletion by
commercially available leukocyte filter could decrease myocardial injury after
mitral valve surgery.
Methods: Forty patients proposed to have mitral valve surgery were enrolled in this
study. They were randomly allocated to one of these two groups: group 1 had
leukocyte filter and group 2 did not have leukocyte filter during the blood
cardioplegia delivery. Blood samples were drawn from the arterial line before aortic
clamping and 2, 6, 18, 30 hours after removal of the cross clamp for troponin-I level
determination. The recovery profiles were also recorded.
Results: The demographic data and crossclamp time were comparable in both
groups. The leukocyte filter did not cause consistent changes in troponin-I level at
every check point. The intubation time, intensive care unit stay and hospital stay
were also similar. The patients with the leukocyte filter seemed to have less
dopamine dose at ICU admission, but without statistical significance.
Conclusion: Our data did not support the routine use of a commercially available
leukocyte depleting filter for blood cardioplegia delivery in mitral valve surgery
without low LVEF or prolonged cross-clamp time. |
| 關鍵詞 |
leukocyte filter, cardioplegia, troponin-I |
| 分類 |
Original Article |
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