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第58卷 第3期 2025-5
Elevating the standards of scientific editing in clinical surgery: Learning from editorial and journal role models

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第58卷 第3期 2025-5
Improving online physician evaluations for surgeons using sentiment analysis and alternative perspectives

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第58卷 第3期 2025-5
Ensuring ethical and qualified authorship: The key to trustworthiness in clinical surgery journal

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第58卷 第3期 2025-5
Artificial intelligence for academic purpose in clinic surgery: ChatGPT, Turnitin, and false positive

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第58卷 第3期 2025-5
COVID-19, COVID-19 vaccination, risk of cardiac myxoma in view of clinical surgery

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第58卷 第3期 2025-5
Eggplant deformity in penile fracture

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Splenectomy for Klippel-Trenaunay syndrome: Systematic review and case series

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第58卷 第3期 2025-5
Comments on “Risk factors for spinal cord injury without radiographic abnormality in trauma cases at a single trauma center”

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第58卷 第3期 2025-5
Impact of fluorescence-guided surgery on splenic preservation: A case of splenic hydatidosis

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第58卷 第3期 2025-5
Adult pancreatoblastoma presentingwith obstructive jaundice: A case report and literature review

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Pilonidal disease management in young adults: A retrospective analysis of practices in a single tertiary center in Bahrain

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第58卷 第3期 2025-5
Long-term comparative outcomes in patients undergoing transcatheter aortic valve implantation with self-expanding valves versus balloon-expandable valves: A retrospective observational study

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第58卷 第3期 2025-5
Comparative study between the effectiveness of Amnion-CollaGee (Collagen-Gelatin-Elastin) as a biological product wound dressing and conventional dressing on the donor site of the split-thickness skin graft in animals model (rats)

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第58卷 第3期 2025-5
Enhancing mortality Probability Model II predictive accuracy with the lethal triad in intensive care unit trauma patients: A retrospective study

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第58卷 第3期 2025-5
Dr. Shao-Wei Chen's contribution to analysis of outcomes of patients undergoing cardiac surgery and aortic disease: Big data analytics

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第58卷 第2期 2025-3
Predatory publisher and low standard journal: An emerging problem in clinical surgery field

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第58卷 第2期 2025-3
Conflict of interest in clinical surgery: Contemporary concern in digital era

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第58卷 第2期 2025-3
Postpublication redecision and pitfalls of inadequate standards in scientific surgical journals: Important consideration in academic publication

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第58卷 第2期 2025-3
Spontaneous bilateral basal ganglia hemorrhage

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第58卷 第2期 2025-3
Academic characterization of the Formosan Journal of Surgery: A five-year bibliometric analysis

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篇名 Cholelithiasis, cholecystitis, cholecystectomy and the associated risk of colorectal cancer
作者 Po-Li Tsai, Yu-Wen Lin, Jian-Syun Chen, Shu-I Wu, Mei-Feng Chiang, Ming-Jen Chen
卷期/出版年月 56卷4期 (2023/7)
頁次 109-115
摘要 Background: Many studies have suggested that cholelithiasis or cholecystectomy may be associated with risk of colorectal cancer [CRC]. This study aimed to verify CRC risk among cholelithiasis patients who experienced cholecystitis or cholecystectomy or both. Methods: Data of a cholelithiasis cohort (n = 28,267) and a noncholelithiasis cohort (n = 112,948) were retrieved (1:4 ratio) from the Longitudinal Health Insurance Database for comparison of CRC risk. Confounding factors were adjusted in multivariate analysis. A hospital-based cancer registry containing 8156 CRC patients was also examined. Data were statistically analyzed using χ2 test, t test, and Cox proportional-hazards model. Results: Univariate and multivariate analysis showed that having cholelithiasis was associated with increased risk of CRC (crude hazard ratio: 1.533 [95%confidence interval {CI}: 1.423–1.652); adjustedHR: 1.481 [95%CI: 1.375–1.597], respectively, p < 0.001) relative to not having cholelithiasis. Increased CRC incidence among patients with cholelithiasis was higher in the right-sided colon (adjusted HR: 1.452 [95%CI: 1.234–1.709], p < 0.001), and higher in female patients. The trend of higher incidence of right-sided colon cancerwas also seen in the hospital-based cancer registry. Of note, cholecystitis or cholecystectomy was associated with mildly increased CRC risk among cholelithiasis patients. Cholecystitis was associated with increased risk of left-sided CRC. Cholecystitis plus cholecystectomy was associated with increased risk of rectal cancer. Conclusions: These results support that cholelithiasis is associated with increased risk of CRC especially in the right-sided colon and among female patients. Cholecystitis and cholecystectomy may shift cancer to the distal part of the large bowel.
關鍵詞 cholelithiasis; cholecystitis; cholecystectomy; colorectal cancer
分類 Original Article

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