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第58卷 第2期 2025-3
Predatory publisher and low standard journal: An emerging problem in clinical surgery field

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第58卷 第2期 2025-3
Conflict of interest in clinical surgery: Contemporary concern in digital era

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Postpublication redecision and pitfalls of inadequate standards in scientific surgical journals: Important consideration in academic publication

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第58卷 第2期 2025-3
Spontaneous bilateral basal ganglia hemorrhage

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Academic characterization of the Formosan Journal of Surgery: A five-year bibliometric analysis

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第58卷 第2期 2025-3
Supra-sternal reconstruction for a high-hanging fruit like right subclavian artery aneurysm

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Operations for choledochal cysts: A 25-year experience at a tertiary care center in India

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第58卷 第2期 2025-3
A case report: Can a titanised polypropylene mesh (TiMesh) obviate a dual mesh for sandwich technique for parastomal hernias?

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第58卷 第2期 2025-3
Recurrent gallstone ileus, a deadly encounter: A case report

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第58卷 第2期 2025-3
The changes in dietary intake and tolerance for Chinese food after bariatric surgery in Taiwan

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第58卷 第2期 2025-3
Diagnostic value of trans-recto-perineal ultrasound in perianal fistula—preoperative versus intraoperative findings: A comparative cross-section study

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第58卷 第2期 2025-3
Efficacy and safety of extended-release dinalbuphine sebacate for postoperative analgesia: A systematic review and meta-analysis

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第58卷 第2期 2025-3
Dynamic changes in segmented neutrophil-to-monocyte ratio in trauma patients with stress-induced hyperglycemia: A retrospective study

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第58卷 第1期 2025-1
Ensuring authorship qualification in clinical research articles: A focus on surgical therapy studies

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第58卷 第1期 2025-1
Estimated risk for transfusion of monkeypox contaminated perioperative blood transfusion: A call to action for stronger regulations and testing protocols

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第58卷 第1期 2025-1
Insights into traumatic and crisis surgery: Implications of data analysis in conflict zones

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第58卷 第1期 2025-1
Tongue peeling as an adverse reaction with use of micronized purified flavonoid: A case report

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第58卷 第1期 2025-1
Pilonidal sinus of scrotum: A rare clinical entity

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第58卷 第1期 2025-1
Incidental autopsy finding of retiform hemangioendothelioma of the spleen

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第58卷 第1期 2025-1
Retroperitoneal laparoscopy for hydronephrosis due to multiple fibroepithelial polyps: A case series

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篇名 Cholelithiasis, cholecystitis, cholecystectomy and the associated risk of colorectal cancer
作者 Po-Li Tsai, Yu-Wen Lin, Jian-Syun Chen, Shu-I Wu, Mei-Feng Chiang, Ming-Jen Chen
卷期/出版年月 56卷4期 (2023/7)
頁次 109-115
摘要 Background: Many studies have suggested that cholelithiasis or cholecystectomy may be associated with risk of colorectal cancer [CRC]. This study aimed to verify CRC risk among cholelithiasis patients who experienced cholecystitis or cholecystectomy or both. Methods: Data of a cholelithiasis cohort (n = 28,267) and a noncholelithiasis cohort (n = 112,948) were retrieved (1:4 ratio) from the Longitudinal Health Insurance Database for comparison of CRC risk. Confounding factors were adjusted in multivariate analysis. A hospital-based cancer registry containing 8156 CRC patients was also examined. Data were statistically analyzed using χ2 test, t test, and Cox proportional-hazards model. Results: Univariate and multivariate analysis showed that having cholelithiasis was associated with increased risk of CRC (crude hazard ratio: 1.533 [95%confidence interval {CI}: 1.423–1.652); adjustedHR: 1.481 [95%CI: 1.375–1.597], respectively, p < 0.001) relative to not having cholelithiasis. Increased CRC incidence among patients with cholelithiasis was higher in the right-sided colon (adjusted HR: 1.452 [95%CI: 1.234–1.709], p < 0.001), and higher in female patients. The trend of higher incidence of right-sided colon cancerwas also seen in the hospital-based cancer registry. Of note, cholecystitis or cholecystectomy was associated with mildly increased CRC risk among cholelithiasis patients. Cholecystitis was associated with increased risk of left-sided CRC. Cholecystitis plus cholecystectomy was associated with increased risk of rectal cancer. Conclusions: These results support that cholelithiasis is associated with increased risk of CRC especially in the right-sided colon and among female patients. Cholecystitis and cholecystectomy may shift cancer to the distal part of the large bowel.
關鍵詞 cholelithiasis; cholecystitis; cholecystectomy; colorectal cancer
分類 Original Article

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