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第58卷 第3期 2025-5
Elevating the standards of scientific editing in clinical surgery: Learning from editorial and journal role models

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Improving online physician evaluations for surgeons using sentiment analysis and alternative perspectives

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Artificial intelligence for academic purpose in clinic surgery: ChatGPT, Turnitin, and false positive

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COVID-19, COVID-19 vaccination, risk of cardiac myxoma in view of clinical surgery

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Eggplant deformity in penile fracture

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Comments on “Risk factors for spinal cord injury without radiographic abnormality in trauma cases at a single trauma center”

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Impact of fluorescence-guided surgery on splenic preservation: A case of splenic hydatidosis

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Adult pancreatoblastoma presentingwith obstructive jaundice: A case report and literature review

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Long-term comparative outcomes in patients undergoing transcatheter aortic valve implantation with self-expanding valves versus balloon-expandable valves: A retrospective observational study

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Comparative study between the effectiveness of Amnion-CollaGee (Collagen-Gelatin-Elastin) as a biological product wound dressing and conventional dressing on the donor site of the split-thickness skin graft in animals model (rats)

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Enhancing mortality Probability Model II predictive accuracy with the lethal triad in intensive care unit trauma patients: A retrospective study

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Dr. Shao-Wei Chen's contribution to analysis of outcomes of patients undergoing cardiac surgery and aortic disease: Big data analytics

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第58卷 第2期 2025-3
Predatory publisher and low standard journal: An emerging problem in clinical surgery field

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Conflict of interest in clinical surgery: Contemporary concern in digital era

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Postpublication redecision and pitfalls of inadequate standards in scientific surgical journals: Important consideration in academic publication

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Spontaneous bilateral basal ganglia hemorrhage

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Academic characterization of the Formosan Journal of Surgery: A five-year bibliometric analysis

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篇名 Animal Model of Lung Cancer Metastasis: Comparison of Efficiency of Propagating Human Lung Cancer Cell Lines in SCID Mice with Intrabronchial, Percutaneous Intrathoracic, and Subcutaneous Routes
作者 Wu-Wei Lai, Fen-Fen Chen, Chau-Yin Chen, Hsiao-Sheng Liu
卷期/出版年月 31卷2期 (1998/4)
頁次 90-96
摘要 An ideal animal model for spontaneous metastasis of human lung cancer may provide better insight into the growth, progression, and metastasis of cancer cells, as well as an opportunity to develop methods for its control. Five human lung cancer cell lines (SK-LU-1, Calu-1, H2981, NCI-Hut 125, and CH-27 LC-1) were selected in an attempt to develop such a model. The tumorigenic potential of these cells was initially assessed by their ability to form colonies in semisolid soft agar (0.33%). Subsequently, SCID mice were inoculated with these cell lines through three different routes, i.e. intra-bronchial (i.b.) instillation, percutaneous intrathoracic (p.t.), and subcuta-neous (s.c.), and the results were evaluated. Human adenocarcinoma cell line H2981 formed colonies in semisolid soft agar and correspondly, showed higher tumorigenic potential in SCID mice. The tumors formed by s.c. im-plantation were encapsulated and led to no metastasis. The percentage of tumor formation of five human lung cancer cell lines in SCID mice with p.t. implantation were 60% (3/5) for H2981, 40% (2/5) for NCI-Hut 125 and no growth for the other three cell lines. Extensive pleural and chest wall in-volvements without lung parenchyma lesion or metastasis resulted from p.t. implantation. On the contrary, the mice inoculated through the i.b. route had lung parenchyma tumors and regional mediastinal lymph node meta-stases were noted in 66% (4/6) of tumor-bearing mice. In conclusion, in- oculation of SCID mice through the i.b. route stimulates tumor formation similar to lung cancer formation in human patients. Thus, this method is useful for in vivo studies of spontaneous metastatic biology and experimen-tal therapeutics for advanced lung cancer.
關鍵詞 Key words: spontaneous metastasis, intrabronchial implantation, SCID mice, nonsmall cell lung cancer
分類 Original Articles

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