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篇名	Effect of Cimetidine on Arylamine N-acetyltransferase Activity in Helicobacter Pylori from Peptic Ulcer Patients
作者	Chi-Fu Hung, Jing-Gung Chung
卷期/出版年月	31卷2期 (1998/4)
頁次	84-89
摘要	Effects of cimetidine on arylamine N-acetyltransferase (NAT) activities in Helicobacter pylori (H. pylori) was determined using acetyl coenzyme-a recycling assay and high pressure liquid chromatography. Cytosols (subcellular fraction) and suspensions (intact bacteria) of H. pylori, with or without selected cimetidine treatment showed decreased acetylation of 2-aminofluorene and p-aminobenzoic acid, indicating that cimetidine reduced the NAT activity of H. pylori. Thus, the usage of cimetidine may help in the prevention of gastric carcinoma by reducing the NAT activity of H. pylori.
關鍵詞	N-acetyltransferase, cimetidine, helicobacter pylori, gastric cancer
分類	Original Articles