| 篇名 |
Arylamine N-Acetyltransferase Activity in Human Placenta and Umbilical Cord |
| 作者 |
Jane-Her Lee, Kuo-Chi Ku, Jen-Liao, Stevenson Ong , Jing-Gung Chung, Chi-Fu Hung |
| 卷期/出版年月 |
31卷2期 (1998/4) |
| 頁次 |
79-83 |
| 摘要 |
N-acetyltransferase (NAT) activity was determined in human placenta and umbilical cord tissues from thirty individual samples. The results derived
from tissue cytosols (subcellular fraction) show that there are 10 rapid, 8
intermediate, and 12 slow acetylators, based on 2-aminofluorene (AF) and p
-aminobenzoic acid (PABA) substrates. The mean activity of placenta and
umbilical cord tissues for AF is 2.67 -0.72 and 2.58-0.36 (n=10), 1.30土0.436
and 1.44-0.31 (n=8), 0.96-0.24 and 0.54士0.12 (n=12) nmol/min/mg protein,
for PABA is 2.26-0.45 and 2.240.32 (n=10), 1.180.26 and 1.180.26 (n=8),
0.74-0.20 and 0.47-0.11 (n=12) nmol/min/mg protein, respectively. The placenta and umbilical cord are not only a conduit between fetus and maternal circulation, but the acetylation capacity of N-acetyltransferase in human placenta and umbilical cord may be also one means of detoxification of foreign chemicals (xenobiotics) from maternal circulation. |
| 關鍵詞 |
acetylation, N-acetyltransferase, placenta, umbilical cord |
| 分類 |
Original Articles |
