|
|
第57卷 第2期 2024-3
Necrotizing fasciitis resulted from foreign body ingestion and intestinal perforation in an incisional hernia: Report of a case |
| ......................... |
|
第57卷 第2期 2024-3
Application of artificial intelligence in endodontic microsurgery |
| ......................... |
|
第57卷 第2期 2024-3
A rare case of cerebral metastasis of malignant peripheral nerve sheath tumor in a patient with neurofibromatosis type 1 |
| ......................... |
|
第57卷 第2期 2024-3
Ethic in commenting and clinical surgery journal publication: Emerging issue in the era of social media—A story from “Beall” to “Jaime” and independent researcher |
| ......................... |
|
第57卷 第2期 2024-3
Ophidascaris robertsi, the new emerging human parasite and neurosurgery |
| ......................... |
|
第57卷 第2期 2024-3
Tetanus toxoid IgG, usefulness in clinical surgery, and diagnostic property limitation |
| ......................... |
|
第57卷 第2期 2024-3
Deaths among surgeons while on duty: An important issue in surgery and occupational medicine that should not be disregarded |
| ......................... |
|
第57卷 第2期 2024-3
ChatGPT and its use in clinical surgery: A comment on its pro and con |
| ......................... |
|
第57卷 第2期 2024-3
Isolated spinal neurocysticercosis and pseudotumor cerebri: Tropical problem to be noted |
| ......................... |
|
第57卷 第2期 2024-3
Management of massive hemothorax resulting from traumatic diaphragm rupture with kidney avulsion injury by combined anterior thoracoabdominal approaches |
| ......................... |
|
第57卷 第2期 2024-3
Laparoscopic partial splenectomy for sclerosing angiomatoid nodular transformation: A case report and literature review |
| ......................... |
|
第57卷 第2期 2024-3
Using three-dimensional versus two-dimensional laparoscopy in sleeve gastrectomy: A case matched comparison |
| ......................... |
|
第57卷 第2期 2024-3
Effectiveness of placing prophylactic mesh with the Sugarbaker technique via laparoscopic abdominoperineal resection for rectal cancer: 1-year results |
| ......................... |
|
第57卷 第2期 2024-3
Nylon cable ties–assisted delay primary closure of fasciotomy wound in patients of forearm compartment syndrome |
| ......................... |
|
第57卷 第2期 2024-3
Prefabricated venous fl ap, an advanced free venous fl ap for distant transfer: An experimental rat study |
| ......................... |
|
第57卷 第1期 2024-1
Isolated lower leg monoplegia due to traumatic intraparenchymal hemorrhage |
| ......................... |
|
第57卷 第1期 2024-1
Reflections on the association between cholecystectomy, cholelithiasis, and colorectal cancer |
| ......................... |
|
第57卷 第1期 2024-1
Molluscum contagiosum, false positive, and incidence: Concern in surgery |
| ......................... |
|
第57卷 第1期 2024-1
New form of COVID-19 vaccine: A new advanced technology for fighting the remained problem |
| ......................... |
|
第57卷 第1期 2024-1
COVID-19 vaccination, acute appendicitis, interrelationship, and jointed probability: A concern |
| ......................... |
|
 |
| 篇名 |
Photodynamic Diagnosis Using Photofrin® for Induced Malignant Oral Lesions in an Animal Model |
| 作者 |
Muh-Shi Lin, Sally M H Cheng, Pei-Shu Hwang, Cheng-Jen Chang |
| 卷期/出版年月 |
39卷1期 (2006/2) |
| 頁次 |
9-18 |
| 摘要 |
Objective: The prognosis of patients suffering from oral cancer can be improved by
early diagnosis. Exact demarcation of tumor margins could contribute to optimal
results in surgical excision and reconstruction. Therefore, this study evaluates
Photofrin® with protoporphyrin IX (PPXI) fluorescence as a new diagnostic procedure
for the detection of oral neoplasms in animal models. The aim of this study is
to assess these parameters, which can be extended to clinical applications for human
oral neoplasms.
Methods: Fourteen male Golden Syrian hamsters were included in this study. 0.5%
D.M.B.A (9,10 dimethyl1-1, 2-benzanethracene), was brushed onto the cheek pouches
bilaterally daily for 2 weeks. Hamsters with oral neoplasms received 2.5mg/kg
Photofrin® intravenously. After a period of 3 hours, the neoplasms underwent fluorescence
illumination ( ex = 380-420 nm). A quantitative analysis of the fluorescence
contrast between the neoplastic and surrounding tissues was performed using the
RGB Mode (Red, Green, Blue) and the GS (Gray Scale). Statistical analysis was performed
by means of ANOVA test for multiple comparisons.
Results: Analysis of the 14 hamsters 28 biopsies revealed that 4 (14%) displayed
squamous hyperplasia (1 mild, 3 severe) and 24 (86%) displayed squamous cell carcinoma.
The sensitivity of neoplastic tissue evaluated using the RGB and GS modes
combined reached 92% in the macroscopic study, and 93% in the microscopic study.
The specificity of neoplastic tissue evaluated using the RGB and GS modes combined
reached 95% in the macroscopic study, and 97% in the microscopic study. The difference
between healthy tissue and the lesions as a group is statistically significant.
Conclusions: Light-induced fluorescence detection using Photofrin® provides a sensitive
technique for the early identification of malignant neoplasms in the oral cavity
of our animal models. |
| 關鍵詞 |
Photofrin®, photodynamic diagnosis, oral neoplasms, hamster |
| 分類 |
Original Article |
|
