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| 篇名 |
Magnolol Modifies the Cytokine Response after Sublethal Hemorrhage |
| 作者 |
Hsin-Chin Shih, Jackson Jerkan Wu, Mu-Shun Huang, Chun-I Huang, Chen-Hsen Lee |
| 卷期/出版年月 |
39卷1期 (2006/2) |
| 頁次 |
1-8 |
| 摘要 |
Objective: This study examined whether cytokine response accompanied by sublethal
hemorrhage (SLH) might be modified by treatment with magnolol.
Methods: Rats were randomly segregated into three experimental groups. The
control group rats received sham-operations and vehicle treatment. The untreated
group rats received SLH and vehicle treatment. The treated group rats received SLH
and magnolol treatment. All animals were subjected to subsequent lethal endotoxin
challenge 24 hours later. Plasma TNF-alpha and IL-10 levels, lipid peroxidation, and
superoxide dismutase (SOD) activity in the lung were measured following SLH or
endotoxin challenge.
Results: Plasma TNF-alpha increased after SLH in both the treated and untreated
groups, whereas a significant lower level was noted in the treated group compared
with the untreated group. After endotoxin sepsis, blunting of the TNF-alpha levels
were found in both the treated and untreated groups. The plasma IL-10 level
increased significantly in the treated group compared with that in the untreated and
control groups. Lipid peroxidation and SOD activity increased after SLH in the
untreated group. Magnolol suppressed the lipid peroxidation but not the SOD
activity. After endotoxin, lipid peroxidation was higher in the control group compared
with that in the treated and untreated groups. Survival analysis showed that
outcome was not different between the treated and untreated groups.
Conclusion: Magnolol modifies the response of cytokines and decreases their
oxidative activity after SLH. Magnolol increases IL-10 response and preserves SOD
activity after SLH, although the final outcome after subsequent endotoxin challenge
is not altered significantly. |
| 關鍵詞 |
sublethal hemorrhage, endotoxin tolerance, cytokine, antioxidant |
| 分類 |
Original Article |
|
