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| 篇名 |
Enteric bacterial loads are associated with interleukin-6 levels in systemic inflammatory response syndrome patients |
| 作者 |
Tzyy-Bin Tsay, Ming-Chieh Yang, Jen-Tang Sun, Pei-Hsuan Chen, Ying-Sheng Lin, Meng-Hung Shih, Lee-Wei Chen |
| 卷期/出版年月 |
49卷6期 (2016/12) |
| 頁次 |
208-216 |
| 摘要 |
Background: Loss of intestinal integrity is a critical contributor to excessive inflammation following severe trauma or major surgery. In the case of enterocyte damage, intestinal fatty acid-binding protein (IFABP) is released into the extracellular space. Excessive production of interleukin (IL)-6 can induce systemic inflammatory response syndrome (SIRS). However, the correlation of IL-6 with gut barrier failure and bacterial translocation in critically ill patients has not been well characterized.
Purposes: To define the relationship between enteric bacterial loads and IL-6 levels in patients with SIRS.
Methods: Variables related to prognosis and treatment were measured in 85 patients with SIRS upon admission to the emergency room. IL-6 and IFABP were measured using an enzyme-linked immunosorbent assay. Enteric bacterial loads in blood were measured through quantitative real-time polymerase chain reaction with primers specific for enteric bacteria.
Results: Multivariate analysis revealed a positive correlation between enteric bacterial loads and IL-6 levels in blood. Elevated IFABP concentration was associated with low blood pressure, high respiration rate, hyperglycemia, and high Sequential Organ Failure Assessment score. Elevated C-reactive protein concentrations were associated with higher soluble CD14 levels in blood.
Conclusion: Enterocyte damage is associated with hypotension and tachypnia in patients with SIRS. Gut function failure may permit enteric bacteria to enter the blood, thereby elevating IL-6 levels and inducing a systemic inflammatory response, resulting in multiple organ failure. |
| 關鍵詞 |
enteric bacterial loads;IFABP;IL-6;SIRS;trauma |
| 分類 |
Original Article |
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