| 摘要 |
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal malignant
cancers, ranks fifth in mortality related to cancer worldwide and tenth in Taiwan
with a 5-year survival rate after resection ranging from 10 to 29%. Improvement of
survival needs diagnosis of early pancreatic cancer which can be defined on the basis
of resectability, size or curability. In order to define early pancreatic cancer, aiming
at better surgical results, early pancreatic cancer has been sought and defined. Small
PDAC is defined as a tumor ≤ 2 cm in size, and it is usually asymptomatic or has
only non-specific symptoms. It was previously considered as an early cancer, with its
diagnosis based on the TNM and Japan Pancreas Society classification defining a T1
tumor as less than 2 cm in diameter. In recent reports, lymph node metastasis, tumor
differentiation, and local infiltration, but not tumor size, were deemed as the
independent predictors of PDAC. Hence, small PDAC should not be regarded as an
early pancreatic cancer, and aggressive management such as surgery plus postoperative
chemotherapy and radiation is justified. |
