| 摘要 |
A study of oral vitamin E tolerance (VETT) was conducted on 36 adults with obstructive jaundice. The patients were divided into two groups depending upon the biliary decompression procedures they have receivεd. Group A was composed of 16 patients who had received cholecystoduodenostomy to relieve biliary obstruction caused by pancreatic head tumors. Group B was composed of 20 patients who had received percutaneous transhepatic biliary diainage (PTBD) to relieve their biliary obstruction. Oral VETTs were performed in both groups before and after relieving biliary obsturction. The vitamin E status for the 36 obstructive-jaundiced patients (Group A+ Group B), assessed after an overnight fast, was 8.2 ± 3.6 μg/ml, a value lower than the control's (9;5±2.5 μg/ml, M±SD). The oral VETT done on the 36 jaundiced patients showed no significant rise in serum vitamin E above the baseline value. The observed maximal absorption of vitamin E ( △ E) in the 36 obstrutive jaundiced patients was significantly lower than in controls (0.78±1.5 vs. 4.2 ±2.5 μg/ml, p<0.001). Postsurgically, the observed 6 E in Group A was markedly higher than it was before surgery (2.0±1.1 vs. 0.78 ± 1.5 μg/ml, p<0.01). This suggested that resumption of bile juice flow to the intestinal tract facilitated intestinal absorption of vitamin E. However, patients in Group B exhibited no r ise in the absorption of vitamin E, even though PTBD did relieve their biliary obstruction. The 6 E observed in Group B after reversal of biliary obst ruction was also markefly lower than that observed in Group A (0.3± 0.8 vs. 2.0± 1.1 μ/ml, p<0.001). This implied that relief of biliary obstruction without resumption of bile juice flow to the intestinal tract would not improve absorption of vitamin E from the intestine. |
