| 篇名 |
N-Acetyltransferase in Healthy Human Liver and Hepatoma Tissues |
| 作者 |
Chi-Fu Hung, Jing-Gung Chung, Jau-Hung Lee, Jen Liao |
| 卷期/出版年月 |
31卷1期 (1998/2) |
| 頁次 |
25-29 |
| 摘要 |
N-acetyltransferase (NAT) is involved in the activation of arylamines through N-acetylation to cause colon and bladder carcinoma. NAT activity was determined in hepatocellular carcinoma (n=30) and healthy liver tissues (n=30) using an acetyl CoA recycling assay and high pressurc liquid chromatography. The activities (Mean+SD) of NAT from healthy liver and hepatoma tissues were 3.60-0.98and 2.18-0.44 nmol/min/mg protein for the acetylation of aminofluorene, 3.02-0.69 and 1.98t0.42 nmol/min/mg protein for the acetylation of p-aminobenzoic acid, respectively. From the results in this study, the hepatoma NAT activity was lower than the healthy liver NAT activity. Thus, we conclude that arylamine is not a carcinogen to hepatoma. |
| 關鍵詞 |
N-acetyltransferase (NAT), arylamine, acetylation, liver, hepatoma. |
| 分類 |
Original Articles |
